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| Status |
Public on Apr 13, 2011 |
| Title |
Molecular characterization of immortalization of human MSCs by a combination of p53 knockdown and TERT overexpression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Gene expression profile of p53 knockdown MSCs or p53 knockdown+TERT MSCs was compared with that of control MSCs. Our data show p53 knockdown prolongs the lifespan of MSCs, and a combination of p53 knockdown and TERT overexpression is sufficient to immortalize MSCs. The results provide important information about the molecular basis underlying p53 knockdown in MSCs and immortalization-related genes of MSCs.
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| Overall design |
Total RNA obtained from p53 knockdown MSCs or p53 knockdown+TERT MSCs from three patients were compared with control MSCs.
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| Contributor(s) |
Liu TM, Lee EH, Lim B |
| Citation(s) |
22765508 |
| Submission date |
Apr 12, 2011 |
| Last update date |
Mar 02, 2022 |
| Contact name |
Tongming Liu |
| E-mail(s) |
dbsliutm@yahoo.com
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| Organization name |
Genome Institute of Singapore
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| Department |
Cancer stem group
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| Street address |
60 Biopolis street
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| City |
Singapore |
| ZIP/Postal code |
138972 |
| Country |
Singapore |
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| Platforms (1) |
| GPL6883 |
Illumina HumanRef-8 v3.0 expression beadchip |
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| Samples (9)
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| GSM706869 |
Patient 2, Control, rep2 |
| GSM706870 |
Patient 2, P53KD+TERT, rep2 |
| GSM706871 |
Patient 2, P53KD, rep2 |
| GSM706872 |
Patient 3, Control, rep3 |
| GSM706873 |
Patient 3, P53KD+TERT, rep3 |
| GSM706874 |
Patient 3, P53KD, rep3 |
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| Relations |
| BioProject |
PRJNA139059 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE28546_RAW.tar |
3.9 Mb |
(http)(custom) |
TAR |
| GSE28546_non-normalized.txt.gz |
925.3 Kb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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