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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Apr 11, 2012 |
| Title |
RNA interference screening identifies the Insulin/IGF-1 receptor pathway as a mechanism of escape from hormone dependence in breast cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation.
A kinome-wide siRNA screen identified a role for Insulin Receptor (InsR) in the hormone-independent growth of ER+ breast cancer cells
We used gene expression microarrays to identify genes and pathways that are altered by insulin stimulation of ER+ MCF-7 human breast cancer cells.
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| Overall design |
MCF-7 cells were treated with serum-free medium +/- insulin for 4 or 24 hrs prior to RNA harvest for analysis.
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| Contributor(s) |
Fox E, Miller T, Arteaga C |
| Citation(s) |
21908557 |
| Submission date |
Apr 13, 2011 |
| Last update date |
Apr 20, 2018 |
| Contact name |
Todd W Miller |
| E-mail(s) |
todd.miller@vanderbilt.edu
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| Organization name |
Vanderbilt Univ
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| Department |
Medicine
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| Street address |
2220 Pierce Ave, 777 PRB
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| City |
Nashville |
| State/province |
TN |
| ZIP/Postal code |
37174 |
| Country |
USA |
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| Platforms (1) |
| GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA139131 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE28580_RAW.tar |
19.8 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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