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| Status |
Public on Jan 11, 2012 |
| Title |
SRC1 gene regulation in endocrine resistant breast cancer cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The development of breast cancer resistance to endocrine therapy results from an increase in cellular plasticity leading to the development of a steroid independent tumour. The p160 steroid coactivator protein SRC-1, through interactions with developmental proteins and other non-steroidal transcription factors drives this tumour adaptability. Here, using discovery studies we identify ADAM22, a non-protease member of the ADAMs family, as a direct target of SRC-1, independent of estrogen receptor(ER). Molecular, cellular, in vivo and clinical studies confirmed SRC-1 as a regulator of ADAM22 and established a role for ADAM22 in endocrine resistant tumour progression. ADAM22 has the potential to act as a therapeutic drug target and a companion predictive biomarker in the treatment of endocrine resistant breast cancer.
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| Overall design |
14 samples representing 4 conditions were analysed. Samples were transfected with either a siRNA targetting SRC1 or a control scrambled siRNA. Samples were subject to tamoxifen treatment or untreated.
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| Contributor(s) |
McCartan D, Bolger J, Fagan A, Byrne C, Hao Y, Qin L, McIlroy M, Xu J, Hill A, Ó Gaora P, Young L |
| Citation(s) |
22072566, 24648347 |
| Submission date |
Apr 15, 2011 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Yuan Hao |
| E-mail(s) |
yuan.hao@ucd.ie
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| Organization name |
UCD
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| Street address |
Bioinformatics,Conway Institute, UCD
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| City |
Dublin |
| State/province |
Ireland |
| ZIP/Postal code |
4 |
| Country |
Ireland |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (14)
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| GSM709764 |
LY2 control-siRNA tamoxifen treated rep2 |
| GSM709765 |
LY2 SRC1-siRNA untreated rep3 |
| GSM709766 |
LY2 control-siRNA tamoxifen treated rep3 |
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| Relations |
| BioProject |
PRJNA138957 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE28645_RAW.tar |
70.7 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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