|
| Status |
Public on Mar 31, 2014 |
| Title |
Hippocampal CA3 Transcriptome Signature and Dentate Gyrus MRI Features Correlate with Initial Precipitating Injury in Refractory Temporal Lobe Epilepsy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We analyzed the transcriptomic profile of CA3 explants surgically obtained from patients with refractory MTLE (mesial temporal lobe epilepsy) and HS (hippocampal sclerosis) in order to investigate if the initial precipitating injury (IPI) influences the molecular mechanisms underlying this condition. CA3 transcriptomic profile was found to be significantly different in cases with prolonged febrile seizures as the IPI (identified here as FS) when compared to correspondent data from cases without febrile seizure history (NFS).
|
| |
|
| Overall design |
CA3 transcriptomic profiles of FS and NFS were compared in order to identify differentially expressed transcripts
|
| |
|
| Contributor(s) |
Bando SY, Alegro MC, Amaro E Jr, Silva AV, Castro LH, Wen HT, Lima LA, Brentani H, Moreira-Filho CA |
| Citation(s) |
22022585, 24278214 |
| Submission date |
Apr 17, 2011 |
| Last update date |
Jan 23, 2019 |
| Contact name |
Carlos Alberto Moreira-Filho |
| E-mail(s) |
carlos.moreira@hc.fm.usp.br
|
| Phone |
55-11-3061-8449
|
| Organization name |
Faculdade de Medicina da Universidade de Sao Paulo
|
| Department |
Departments of Pediatrics
|
| Lab |
LIM36
|
| Street address |
Av. Dr. Eneas Carvalho de Aguiar 647
|
| City |
Sao Paulo |
| State/province |
SP |
| ZIP/Postal code |
05403-900 |
| Country |
Brazil |
| |
|
| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
|
| Samples (18)
|
| GSM710293 |
hippocampus_CA3_febrile seizure FS1 |
| GSM710294 |
hippocampus_CA3_febrile seizure FS2 |
| GSM710295 |
hippocampus_CA3_febrile seizure FS4 |
| GSM710296 |
hippocampus_CA3_febrile seizure FS5 |
| GSM710297 |
hippocampus_CA3_febrile seizure FS6 |
| GSM710298 |
hippocampus_CA3_febrile seizure FS7 |
| GSM710299 |
hippocampus_CA3_no-febrile seizure NFS9 |
| GSM710300 |
hippocampus_CA3_no-febrile seizure NFS10 |
| GSM710301 |
hippocampus_CA3_no-febrile seizure NFS11 |
| GSM710302 |
hippocampus_CA3_no-febrile seizure NFS12 |
| GSM710303 |
hippocampus_CA3_no-febrile seizure NFS15 |
| GSM710304 |
hippocampus_CA3_no-febrile seizure NFS16 |
| GSM710305 |
hippocampus_CA3_no-febrile seizure NFS17 |
| GSM710306 |
hippocampus_CA3_no-febrile seizure NFS18 |
| GSM710307 |
hippocampus_CA3_no-febrile seizure NFS19 |
| GSM710308 |
hippocampus_CA3_no-febrile seizure NFS20 |
| GSM710309 |
hippocampus_CA3_no-febrile seizure NFS22 |
| GSM710310 |
hippocampus_CA3_no-febrile seizure NFS23 |
|
| Relations |
| BioProject |
PRJNA138925 |
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