|
| Status |
Public on Feb 16, 2012 |
| Title |
Gene expression analysis of human serious ovarian tumors and fimbria control |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The cell of origin of serious ovarian cancer is unknown. To create a mouse model for this lethal cancer and identify early cancer biomarkers, we conditionally deleted both Dicer (essential for microRNA biosynthesis) and Pten (a negative regulator of the PI3K pathway) in the female reproductive tract. Beginning at ~3-5 months, these Dicer/Pten mutant mice develop high-grade serious carcinomas that initiate in the stroma of the fallopian tube through a mesenchymal-to-epithelial transition (MET), subsequently envelop the ovary, and then metastasize throughout the peritoneum, resulting in ascites and 100% lethality by 13 months. The fallopian tube cancers demonstrate upregulation of genes encoding known and novel secreted proteins that are potential biomarkers. This study uncovers a new paradigm for the initiation of high-grade serous ovarian cancer.
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| Overall design |
We generated gene expression profiles of 8 human primary serious tumors, and 2 independent samples of human normal fimbria. We defined genes that were high or low in tumors relative to fimbria, and compared these results with those of the correponding mouse model.
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| |
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| Contributor(s) |
Creighton C, Matzuk M, Kim J, Hawkins S |
| Citation(s) |
22331912 |
| Submission date |
Apr 19, 2011 |
| Last update date |
Feb 18, 2019 |
| Contact name |
Chad Creighton |
| E-mail(s) |
creighto@bcm.tmc.edu
|
| Organization name |
Baylor College of Medicine
|
| Department |
Biostatistics, Ducan Cancer Center
|
| Street address |
One Baylor Plaza, Mail Stop: BCM305
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL6884 |
Illumina HumanWG-6 v3.0 expression beadchip |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
|
| Samples (10)
|
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| This SubSeries is part of SuperSeries: |
| GSE28979 |
Gene expression profiles of serous ovarian cancer in human and mouse |
|
| Relations |
| BioProject |
PRJNA143109 |
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