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Series GSE29075 Query DataSets for GSE29075
Status Public on May 01, 2012
Title Analysis of hippocampal gene expression in adult and aged male BABL/c mice with or without running wheel access
Organism Mus musculus
Experiment type Expression profiling by array
Summary Currently, the mechanisms behind the anti-aging effects of exercise are not understood. The presented study conducted a microarray on hippocampal samples from adult (3.5 month-old) and aged (18 month-old) male BALB/c mice that were individually housed with or without running wheels for 8 weeks. Results showed that aging altered genes related to chromatin remodeling, cell growth, immune activity, and synapse organization compared to adult mice. Exercise was found to modulate many of the genes altered by aging, but in the opposite direction. For example, wheel running increased expression of genes related to cell growth and attenuated expression of genes involved in immune function and chromatin remodeling. Collectively, findings show that even late-onset exercise may attenuate age-related changes in gene expression and identifies possible pathways through which exercise may exert its beneficial effects.
 
Overall design In total 20 samples (4 aged exercise, 4 aged sedentary, 6 adult exercise, and 6 adult sedentary) plus 4 technical replicates (24 total) were analyzed.
 
Contributor(s) Kohman RA, Rodriguez-Zas SL, Kelley KW, Dantzer R, Rhodes JS
Citation(s) 21857943
Submission date May 04, 2011
Last update date Jan 16, 2019
Contact name Rachel Ann Kohman
Organization name University of Illinois
Department Psychology
Street address 405 N Mathew
City Urbana
State/province IL
ZIP/Postal code 61801
Country USA
 
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (24)
GSM720442 hippocampus adult exercise technical replicate of 13
GSM720443 hippocampus aged exercise no. 2
GSM720444 hippocampus aged sedentary no. 3
Relations
BioProject PRJNA140289

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE29075_RAW.tar 15.8 Mb (http)(custom) TAR
GSE29075_non-normalized.txt.gz 4.2 Mb (ftp)(http) TXT
Processed data included within Sample table
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