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| Status |
Public on Jun 07, 2011 |
| Title |
Effect of FGF15 or FGF19 on mouse liver |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Mouse FGF15 and human FGF19 are orthologous proteins that regulate bile acid metabolism. However, other hepatic functions of FGF15/19 are not well characterized.
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| Overall design |
We used microarrays to analyze global hepatic gene expression in mice administered FGF15 or FGF19. Total liver RNA was isolated from wild-type mice administered vehicle, purified FGF15 or recombinant FGF19 for 6 hr via a jugular vein injection as described (Inagaki et al., 2005). Mice did not have access to food throughout the 6 hr treatment, and livers were harvested and immediately frozen in liquid nitrogen. Microarray analyses were performed using the Mouse Genome 430A 2.0 array.
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| Contributor(s) |
Kliewer S, Mangelsdorf D |
| Citation(s) |
21641554 |
| Submission date |
May 20, 2011 |
| Last update date |
May 04, 2018 |
| Contact name |
Matthew Joseph Potthoff |
| Organization name |
University of Texas Southwestern Medical Center
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| Department |
Pharmacology
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| Lab |
Steven Kliewer and David Mangelsdorf
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| Street address |
6001 Forest Park Rd
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| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75390 |
| Country |
USA |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA141493 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE29426_RAW.tar |
13.3 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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