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Series GSE29507 Query DataSets for GSE29507
Status Public on Dec 31, 2012
Title Gene Expression Profiling of Tuberculous Meningitis coinfected with HIV
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Tuberculosis co-infected with HIV may increase the risk of causing meningitis. Tuberculous meningitis co-infected with HIV associated with high mortality and severe neurological abnormalities in affected individuals. We have carried out TBM co-infected with HIV gene expression study using whole human genome microarrays. We identified 796 differentially expressed genes with fold change cut off of 2 or more than 2. Out of 796 differentially expressed genes, 398 were upregulated and 396 were downregulated. We have validated two molecules from microarray data using immunohistochemistry.
 
Overall design The proposed study carried out mRNA expression profiling of five samples from patients diagnosed with tuberculous meningitis coinfected with HIV and four head injury cases were used as controls. We have used 4X44K arrays from agilent platform. To validate our microarray results, we have done immunohistochemistry on 10 TBM+HIV cases and 10 control groups.
 
Contributor(s) Pandey A
Citation(s) 27053842
Submission date May 24, 2011
Last update date Jul 26, 2019
Contact name Akhilesh Pandey
E-mail(s) pandey@jhmi.edu, arivusudar@ibioinformatics.org, sameerkumar.iob@gmail.com, microarray@ibioinformatics.org
Phone 91 080 28416140
Organization name Institute of Bioinformatics
Street address UnitI, Discoverer building, ITPL
City Bangalore
State/province Karnataka
ZIP/Postal code 560 066
Country India
 
Platforms (1)
GPL4133 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
Samples (9)
GSM568997 Normal_cortex_frozen_tissue_1
GSM568998 Normal_cortex_frozen_tissue_2
GSM568999 Normal_cortex_frozen_tissue_3
Relations
BioProject PRJNA141453

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE29507_RAW.tar 77.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
Processed data provided as supplementary file

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