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| Status |
Public on Jun 06, 2011 |
| Title |
Two Forkhead transcription factors regulate the division of cardiac progenitor cells by a Polo-dependent pathway - I |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by array
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| Summary |
The development of a complex organ requires the specification of appropriate numbers of each of its constituent cell types, as well as their proper differentiation and correct positioning relative to each other. During Drosophila cardiogenesis, all three of these processes are controlled by jumeau (jumu) and Checkpoint suppressor homologue (CHES-1-like), two genes encoding forkhead transcription factors that we discovered utilizing an integrated genetic, genomic and computational strategy for identifying novel genes expressed in the developing Drosophila heart. Both jumu and CHES-1-like are required during asymmetric cell division for the derivation of two distinct cardiac cell types from their mutual precursor, and in symmetric cell divisions that produce yet a third type of heart cell. jumu and CHES-1-like control the division of cardiac progenitors by regulating the activity of Polo, a kinase involved in multiple steps of mitosis. This pathway demonstrates how transcription factors integrate diverse developmental processes during organogenesis.
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| Overall design |
GFP-positive and GFP-negative cells were profiled from Stage 11 TinD-GFP Drosophila embryos.
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| Contributor(s) |
Ahmad SM, Tansey TR, Busser BW, Nolte MT, Jeffries N, Gisselbrecht SS, Rusan NM, Michelson AM |
| Citation(s) |
22814603 |
| Submission date |
May 26, 2011 |
| Last update date |
Jul 06, 2016 |
| Contact name |
Shaad M. Ahmad |
| E-mail(s) |
shaad.ahmad@indstate.edu
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| Organization name |
National Heart Lung and Blood Institute
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| Department |
Systems Biology Center
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| Lab |
Laboratory of Developmental Systems Biology
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| Street address |
Building 10, Room 7N311, 10 Center Drive MSC 1654
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| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL72 |
[DrosGenome1] Affymetrix Drosophila Genome Array |
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| Samples (6)
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| GSM732134 |
GFP-positive cells from TinD-GFP embryos, replicate 1 |
| GSM732135 |
GFP-positive cells from TinD-GFP embryos, replicate 2 |
| GSM732136 |
GFP-positive cells from TinD-GFP embryos, replicate 3 |
| GSM732137 |
GFP-negative cells from TinD-GFP embryos, replicate 1 |
| GSM732138 |
GFP-negative cells from TinD-GFP embryos, replicate 2 |
| GSM732139 |
GFP-negative cells from TinD-GFP embryos, replicate 3 |
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| Relations |
| BioProject |
PRJNA141397 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE29573_RAW.tar |
31.2 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
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