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| Status |
Public on Oct 21, 2011 |
| Title |
Lysyl oxidase-like 2 (LOXL2) a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Basal-like breast carcinoma is characterized by the expression of basal/myoepithelial markers, undifferentiated phenotype, highly aggressive behaviour and a frequent triple negative status (ESR-, PR-, Her2neu-). We have previously shown that epithelial-mesenchymal transition (EMT) occurs in basal-like breast tumours and identified Lysyl- Oxidase-Like 2 (LOXL2) as an EMT player and a poor prognosis marker in squamous cell carcinomas. We now show that LOXL2 mRNA is overexpressed in basal-like human breast carcinomas.
Identification of new molecular markers in basal breast carcinomas
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| Overall design |
58 (IDC) infiltrative breast ductal carcinoma samples (Grade 3)
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| Contributor(s) |
Moreno-Bueno G, Salvador F, Martin A, Floristan A, Cuevas EP, Santos V, Montes A, Morales S, Castilla MA, Rojo-Sebastian A, MartÃnez A, Hardisson D, Csiszar K, Portillo F, Peinado H, Palacios J, Cano A |
| Citation(s) |
21732535 |
| Submission date |
May 27, 2011 |
| Last update date |
Dec 06, 2012 |
| Contact name |
Gema Moreno-Bueno |
| E-mail(s) |
gmoreno@iib.uam.es
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| Phone |
+34914978974
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| Organization name |
IIB
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| Department |
Biochemistry
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| Lab |
1.13
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| Street address |
Arturo Duperier
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| City |
Madrid |
| State/province |
Madrid |
| ZIP/Postal code |
28029 |
| Country |
Spain |
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| Platforms (1) |
| GPL887 |
Agilent-012097 Human 1A Microarray (V2) G4110B (Feature Number version) |
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| Samples (58)
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| Relations |
| BioProject |
PRJNA141413 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE29581_RAW.tar |
341.8 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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