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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jun 01, 2011 |
| Title |
Expression data from 9 and 13 weeks old TIFIAD1Cre mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We have investigated the p53-dependent stress response in medium spiny neurons (MSNs) that degenerate in Huntington’s disease. To induce p53 signaling cascade, we have genetically inactivated by the Cre/loxP system the essential RNA polymerase I (Pol I) transcription factor TIF-IA, leading to stabilization of p53 and induction of p53-dependent apoptosis.
In the present study, we selectively ablated the TIF-IA gene in MSNs by crossing TIF-IAflox/flox mice, homozygous for the floxed TIF-IA allele with transgenic mice expressing the Cre recombinase under the control of the D1 dopamine receptor (D1R) promoter.
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| Overall design |
To explore the molecular mechanisms underlying survival and death we profiled global gene expression in 9 and 13 week old control and TIF-IAD1RCre mutant mice (3 mice/each timepoint For each of the four conditions, five GeneChips were used each )
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| Contributor(s) |
Parkitna JR, Kreiner G, Schütz G, Parlato R |
| Citation(s) |
23764776 |
| Submission date |
Jun 01, 2011 |
| Last update date |
May 04, 2018 |
| Contact name |
Grzegorz Kreiner |
| E-mail(s) |
kreiner@if-pan.krakow.pl
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| Organization name |
Institute of Pharmacology
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| Department |
Dept. Brain Biochemistry
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| Street address |
Smetna 12
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| City |
Krakow |
| ZIP/Postal code |
31-343 |
| Country |
Poland |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (12)
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| GSM735016 |
9weeks, mutant, biol.rep1 |
| GSM735017 |
9weeks, mutant, biol.rep2 |
| GSM735018 |
9weeks, mutant, biol.rep3 |
| GSM735019 |
13weeks, control, biol.rep1 |
| GSM735020 |
13weeks, control, biol.rep2 |
| GSM735021 |
13weeks, control, biol.rep3 |
| GSM735022 |
13weeks, mutant, biol.rep1 |
| GSM735023 |
13weeks, mutant, biol.rep2 |
| GSM735024 |
13weeks, mutant, biol.rep3 |
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| Relations |
| BioProject |
PRJNA141231 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE29647_RAW.tar |
38.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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