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Series GSE29658 Query DataSets for GSE29658
Status Public on Jun 02, 2011
Title The transcriptional repressor Blimp1/Prdm1 regulates post-natal reprogramming of intestinal enterocytes
Organism Mus musculus
Experiment type Expression profiling by array
Summary Expression profiling of Prdm1 mutant E18.5 small intestine was performed using Illumina whole genome V2 arrays. The hypothesis tested in the present study was that Blimp1 regulates the transcription of key genes involved in enterocyte differentiation and survival. Results identify substantial and premature activation of key components of the adult enterocyte biochemical signature.
 
Overall design Villin-Cre and Prdm1BEH/+ animals were intercrossed to generate heterozygous Villin-Cre, Prdm1BEH males that were then mated with homozygous Prdm1 CA/CA females carrying the R26R allele to generate Prdm1+/+ (Prdm1CA/+) or Prdm1-/- (Villin-Cre, Prdm1CA/BEH) offspring. Total RNA obtained from 11 Prdm1+/+ and 10 Prdm1-/- E18.5 small intestine samples was hybridized to Illumina WG6_V2 beadchips.
 
Contributor(s) Harper J, Mould A, Andrews R, Bikoff E, Robertson E
Citation(s) 21670299
Submission date Jun 01, 2011
Last update date Jan 16, 2019
Contact name Arne Wyndham Mould
E-mail(s) arne.mould@path.ox.ac.uk
Phone +44 1865 285749
Organization name Oxford University
Department Pathology
Lab Robertson/Bikoff
Street address South Parks Road
City Oxford
State/province OXON
ZIP/Postal code OX1 3RE
Country United Kingdom
 
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (21)
GSM735257 Prdm1+/+_1
GSM735258 Prdm1+/+_2
GSM735259 Prdm1+/+_3
Relations
BioProject PRJNA141251

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE29658_RAW.tar 15.8 Mb (http)(custom) TAR
GSE29658_non_normalized.txt.gz 6.0 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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