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| Status |
Public on Nov 01, 2011 |
| Title |
Toxicogenomic Study of Pentamethylchromanol (PMCol) |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
The objective of this study is to determine the molecular mechanisms of PMCol-induced hapatotoxicity using microarray
The study demonstrated that chronic exposure to high doses of PMCol induces liver damage and dysfunction, probably due to both inhibition of synthesis and depletion of liver glutathione as well as modification of other drug metabolism pathways.
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| Overall design |
PMCol was administered to male Sprague-Dawley rats at at doses of 200 and 2000 mg/kg daily for 7 or 28 days
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| Contributor(s) |
Ng HH, Bunin DI, Wang A |
| Citation(s) |
21920950 |
| Submission date |
Jun 01, 2011 |
| Last update date |
Nov 06, 2013 |
| Contact name |
Hanna Hongchin Ng |
| E-mail(s) |
hanna.ng@sri.com
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| Organization name |
SRI International
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| Street address |
333 Ravenswood Avenue
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| City |
Menlo Park |
| State/province |
CA |
| ZIP/Postal code |
94025 |
| Country |
USA |
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| Platforms (1) |
| GPL6247 |
[RaGene-1_0-st] Affymetrix Rat Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (29)
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| GSM735918 |
Control at Day 8, biological rep 4 |
| GSM735919 |
Control at Day 8, biological rep 5 |
| GSM735920 |
Control at Day 8, biological rep 6 |
| GSM735921 |
Control at Day 29, biological rep 1 |
| GSM735922 |
Control at Day 29, biological rep 2 |
| GSM735923 |
Control at Day 29, biological rep 3 |
| GSM735924 |
Control at Day 29, biological rep 4 |
| GSM735925 |
Control at Day 29, biological rep 5 |
| GSM735926 |
Control at Day 29, biological rep 6 |
| GSM735927 |
200 mg/kg PMCol, Day 29, biological rep 1 |
| GSM735928 |
200 mg/kg PMCol, Day 29, biological rep 2 |
| GSM735929 |
200 mg/kg PMCol, Day 29, biological rep 3 |
| GSM735930 |
200 mg/kg PMCol, Day 29, biological rep 4 |
| GSM735931 |
200 mg/kg PMCol, Day 29, biological rep 5 |
| GSM735932 |
200 mg/kg PMCol, Day 29, biological rep 6 |
| GSM735933 |
2000 mg/kg PMCol, Day 8, biological rep 1 |
| GSM735934 |
2000 mg/kg PMCol, Day 8, biological rep 2 |
| GSM735935 |
2000 mg/kg PMCol, Day 8, biological rep 3 |
| GSM735936 |
2000 mg/kg PMCol, Day 8, biological rep 4 |
| GSM735937 |
2000 mg/kg PMCol, Day 8, biological rep 5 |
| GSM735938 |
2000 mg/kg PMCol, Day 8, biological rep 6 |
| GSM735939 |
2000 mg/kg PMCol, Day 29, biological rep 1 |
| GSM735940 |
2000 mg/kg PMCol, Day 29, biological rep 2 |
| GSM735941 |
2000 mg/kg PMCol, Day 29, biological rep 3 |
| GSM735942 |
2000 mg/kg PMCol, Day 29, biological rep 4 |
| GSM735943 |
2000 mg/kg PMCol, Day 29, biological rep 5 |
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| Relations |
| BioProject |
PRJNA141309 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE29673_RAW.tar |
121.7 Mb |
(http)(custom) |
TAR (of CEL) |
| GSE29673_SUPPLEMENTAL_FIGURE-_PCA_analysis_3D.pdf.gz |
28.2 Kb |
(ftp)(http) |
PDF |
| GSE29673_SUPPLEMENTAL_TABLE_1-Up_Day_29_high_dose.pdf.gz |
51.6 Kb |
(ftp)(http) |
PDF |
| GSE29673_SUPPLEMENTAL_TABLE_2-Up_Day_8_high_dose.pdf.gz |
39.5 Kb |
(ftp)(http) |
PDF |
| GSE29673_SUPPLEMENTAL_TABLE_3-Down_Day_29_high.pdf.gz |
125.9 Kb |
(ftp)(http) |
PDF |
| GSE29673_SUPPLEMENTAL_TABLE_4-Down_Day_8_high.pdf.gz |
37.0 Kb |
(ftp)(http) |
PDF |
| Processed data included within Sample table |
| Processed data are available on Series record |
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