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Series GSE3 Query DataSets for GSE3
Status Public on Jul 19, 2001
Title Renal Cell Carcinoma Differential Expression
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We investigated the changes in gene expression accompanying the development and progression of kidney cancer using 31,500 element complementary DNA arrays. We measured expression profiles for paired neoplastic and non-cancerous renal epithelium samples from 37 individuals. Using an experimental design optimized for factoring out technological and biological noise, and an adapted statistical test, we find 1738 differentially expressed cDNAs with an expected number of 6 false positives. Functional annotation of these genes provided views of the changes in the activities of specific biological pathways in renal cancer. Cell adhesion, signal transduction, and nucleotide metabolism were among the biological processes with a large proportion of genes overexpressed in renal cell carcinoma. Downregulated pathways in the kidney tumor cells included small molecule transport, ion homeostasis, and oxygen and radical metabolism. Our expression profiling data uncover gene expression changes shared with other epithelial tumors, as well as a unique signature for renal cell carcinoma. Expression data for the differentially expressed cDNAs are available in the web supplement (http://www.dkfz-heidelberg.de/abt0840/whuber/rcc).
Keywords = renal clear cell carcinoma, kidney
Keywords: other
 
 
Contributor(s) Boer JM, Huber W, Sueltmann H, Wilmer F, von Heydebreck A, Haas S, Korn B, Vente A, Fuzesi L, Vingron M, Poustka A
Citation(s) 11691851
Submission date Jul 19, 2001
Last update date Dec 26, 2017
Contact name Wolfgang Huber
E-mail(s) w.huber@dkfz.de
Phone +49-6221-424709
Fax +49-6221-423470
URL http://www.dkfz-heidelberg.de/abt0840
Organization name German Cancer Research Center
Department Molecular Genome Analysis
Street address Im Neuenheimer Feld 280
City Heidelberg
ZIP/Postal code 69120
Country Germany
 
Platforms (2)
GPL9 Human Unigene I, part 1
GPL10 Human Unigene I, part 2
Samples (342)
GSM81 Renal cell carcinoma: rccc-1, normal 1 (part 1 of 2)
GSM82 Renal cell carcinoma: rccc-1, tumor 1 (part 1 of 2)
GSM83 Renal cell carcinoma: rccc-1, normal 2 (part 1 of 2)
Relations
BioProject PRJNA84759

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Supplementary data files not provided
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