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| Status |
Public on Aug 01, 2013 |
| Title |
IkBa associates with histone H2A in human keratinocytes |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Here, we demonstrate that IkBa displays a predominant and unique nuclear localization in normal basal keratinocytes. This nuclear IkBa binds the chromatin through direct interaction of the ankyrin repeats with histone H2A and associates with the promoter and regulatory regions of several developmental-related genes including HOXA10, HOXB2 and HOXB9. Most importantly, IkBa dictates the competence of these HOX genes to be activated upon TNFa stimulation.
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| Overall design |
Examination of IkBalpha location in keratinocyte cells
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| Contributor(s) |
Espinosa L, Islam A, Mulero MC, Bigas A, Lopez-Bigas N |
| Citation(s) |
23850221 |
| Submission date |
Jun 19, 2011 |
| Last update date |
May 15, 2019 |
| Contact name |
Lluis Espinosa |
| E-mail(s) |
lespinosa@imim.es
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| Phone |
+34-933160589
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| Organization name |
Hospital del Mar
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| Department |
Institut Municipal d'Investigacions Mèdiques, (IMIM)
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| Lab |
Stem Cell and Cancer
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| Street address |
Dr. Aiguader 88
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| City |
Barcelona |
| State/province |
Barcelona |
| ZIP/Postal code |
08003 |
| Country |
Spain |
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| Platforms (1) |
| GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
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| Samples (1) |
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| Relations |
| SRA |
SRP007333 |
| BioProject |
PRJNA144069 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE30082_RAW.tar |
194.5 Mb |
(http)(custom) |
TAR (of BED, WIG) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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