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Series GSE30102 Query DataSets for GSE30102
Status Public on Aug 31, 2011
Title Direct lineage conversion of terminally differentiated hepatocytes to functional neurons
Organism Mus musculus
Experiment type Expression profiling by array
Summary Mouse fibroblasts and hepatocyte can be directly reprogrammed to induced neuronal (iN) cells. Genome-wide expression analysis showed that Hep-iN cells had not only induced a neuronal transcriptional program but also effectively silenced the hepatocyte transcriptome suggesting that the reprogramming factors lead to a binary lineage switch decision rather than an induction of hybrid phenotypes. Similarly, the fibroblast-specific transcriptional program was downregulated in fibroblast-derived iN cells.
BAM = infection with the 3 factors (Ascl1 - Brn2 - Myt1l) .
ATT = Hepatocytes_derived_induced_neurons derived from TauGFP-AlbCre-R26-lsl-tomato
 
Overall design Total RNA obtained from MEFs subjected to 21 days lentivirus infection for neuronal induction compared to uninfected MEFs.
 
Contributor(s) Tsai M, Chang H, Marro S, Wernig M
Citation(s) 21962918
Submission date Jun 20, 2011
Last update date Jun 14, 2018
Contact name Miao-Chih Tsai
E-mail(s) miaochih@gmail.com
Organization name Stanford University
Street address 269 Campus Drive, CCSR 2140
City Stanford
State/province CA
ZIP/Postal code 94305
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (7)
GSM745456 9171_MEF
GSM745457 9172_MEF
GSM745458 9176_neuron
Relations
BioProject PRJNA143891

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE30102_RAW.tar 3.1 Mb (http)(custom) TAR
GSE30102_non_normalized.txt.gz 1.2 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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