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Series GSE3013

Query DataSets for GSE3013

Status

Public on Jul 29, 2005

Title

Actions of tamoxifen in the uterus and its molecular effectors in endometrial carcinogenesis.

Organism

Experiment type

Expression profiling by array

Summary

The molecular explanation for tamoxifen serving as a breast cancer treatment but displaying partial estrogenic in the uterus is not known. Previously, we reported that differential promoter context and cofactor recruitment contribute to the tissue specificity of tamoxifen. Here, we investigated the genomic basis for the partial oestrogenic activity of tamoxifen in the endometrium. We showed that tamoxifen not only affects the rate of transcription of oestrogen target genes but also targets a unique set of genes. Since oestrogen and tamoxifen are both able to bind to oestrogen receptors (ERs) and because both promote endometrial carcinogenesis, we hypothesized that the molecular effectors for ERs in endometrial carcinogenesis most likely reside in genes that are commonly targeted by oestrogen and tamoxifen. Among those target genes, we identified a paired-box gene PAX2 that is critically involved in cell proliferation and carcinogenesis in the endometrium. Our experiments also demonstrated that PAX2 is activated by oestrogen and tamoxifen in endometrial carcinomas but not in normal endometrium, and this activation is associated with cancer-linked hypomethylation of the PAX2 promoter.
Keywords: actions of tamoxifen

Overall design

each experiment repeat 2 times.

Contributor(s)

Citation(s)

Submission date

Jul 27, 2005

Last update date

Dec 13, 2018

Contact name

Yongfeng Shang

E-mail(s)

jason@mail.bjmu.edu.cn

Phone

86-10-82805118

Fax

86-10-82801355

Organization name

Peking University

Department

Biochemistry and Molecular Biology

Street address

38 Xue Yuan Road

City

Beijing

ZIP/Postal code

100083

Country

China

Platforms (2)

GPL91	[HG_U95A] Affymetrix Human Genome U95A Array
GPL8300	[HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array

Samples (18)

More...

GSM64885	EECs from stage I endometrioid carcinomas control rep 1
GSM65277	EECs from stage I endometrioid carcinomas control rep 2
GSM65278	EECs from stage I endometrioid carcinomas oestrogen(E2) rep 1

Relations

BioProject

Download family	Format
SOFT formatted family file(s)	SOFT
MINiML formatted family file(s)	MINiML
Series Matrix File(s)	TXT

Supplementary file	Size	Download	File type/resource
GSE3013_RAW.tar	55.3 Mb	(http)(custom)	TAR (of CEL, EXP)

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