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Series GSE30305 Query DataSets for GSE30305
Status Public on Jun 21, 2012
Title Transcriptional effects of chronic heroin and methamphetamine treatment in the mouse striatum
Organism Mus musculus
Experiment type Expression profiling by array
Summary To identify molecular effects of chronic drug treatment, heroin and methamphetamine treated animals were compared with saline treated animals at multiple time-points using microarray technology. Gene expression profile was assessed 14 h after the last dose of 1, 3, 6 or 12 days drug treatment and after 13, 15, 18 or 24 days of withdrawal.
 
Overall design Animals were injected intraperitoneally with saline (SAL) (Polfa, Lublin, Poland), heroin (synthesized from morphine in Institute of Pharmacology PAS, Krakow, Poland) or D-methamphetamine (Sigma-Aldrich, Poznan, Poland) twice a day for consecutive 12 days in increasing doses. The Methamphetamine last dose (8 mg/kg) was four times greater than the first dose (2 mg/kg). It was also the case for heroin (40 and 10 mg/kg respectively). Mice were sacrificed by decapitation after 1, 3, 6 or 12 days of treatment or after 13, 15, 18 or 24 days of withdrawal.
 
Contributor(s) Piechota M, Korostynski M
Citation(s) 22390687
Submission date Jun 29, 2011
Last update date Jan 16, 2019
Contact name Marcin Piechota
E-mail(s) marpiech@if-pan.krakow.pl
Phone (+4812) 6623328
Organization name Institute of Pharmacology PAS
Department Molecular Neuropharmacology
Street address Smetna 12
City Krakow
ZIP/Postal code 31-343
Country Poland
 
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (78)
GSM751160 Day: 1; Drug: Methamphetamine; Phase: Drug treatment; Replicate: 1
GSM751161 Day: 3; Drug: Heroin; Phase: Drug treatment; Replicate: 2
GSM751162 Day: 6; Drug: Saline; Phase: Drug treatment; Replicate: 3
Relations
BioProject PRJNA143581

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE30305_RAW.tar 15.8 Mb (http)(custom) TAR
GSE30305_non-normalized_data.txt.gz 19.4 Mb (ftp)(http) TXT
Processed data included within Sample table
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