|
| Status |
Public on Jul 01, 2012 |
| Title |
Expression data from FAK null mouse embryonic fibroblasts treated with endothelin-1 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Endothelin-1 (ET-1) plays a critical role in connective tissue remodeling by fibroblasts during tissue repair and fibrosis. We investigated the molecular pathways in the transmission of ET-1 signals that lead to features of connective tissue remodeling, in particular the role of FAK (focal adhesion kinase).
We used microarrays to investigated whether FAK is required for ET-1 to promote the global programme of gene expression underlying myofibroblast formation and identified distinct classes of up-regulated genes during this process. Genes whose induction by ET-1 required FAK
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| |
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| Overall design |
Affymetrix Mouse Genome 430 2.0 GeneChips were used to identify differential gene expression changes bewteen samples.
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| Contributor(s) |
Lagares D, Busnadiego O, Garcia-Fernandez R, Kapoor M, Liu S, Carter DE, Abraham D, Shi-Wen X, Carreira P, Fontaine BA, Shea BS, Tager AM, Leask A, Lamas S, Rodriguez-Pascual F |
| Citation(s) |
22492165 |
| Submission date |
Jul 01, 2011 |
| Last update date |
Feb 11, 2019 |
| Contact name |
David E Carter |
| E-mail(s) |
dcarter@robarts.ca
|
| Organization name |
Robarts Research Institute
|
| Department |
London Regional Genomics Centre
|
| Street address |
1151 Richmond Street North
|
| City |
London |
| State/province |
ON |
| ZIP/Postal code |
N6A5B7 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (4)
|
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| Relations |
| BioProject |
PRJNA143633 |
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