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| Status |
Public on Jul 18, 2011 |
| Title |
VillinCre-Blimpflox mice postpartum day 7 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
In many mammalian species, the intestinal epithelium is immature at birth. During the suckling to weaning transition, the intestine matures. This developmental transition is the result of a genetic program that is intrinsic to the gut and independent of luminal content, but its regulators have not been identified. We investigated the function of the transcriptional repressor Blimp-1 using mice with intestine-specific ablation of Blimp-1. Deletion of Blimp-1 results in growth retardation and excess neonatal mortality. Mutant mice lack all typical epithelial features of the suckling period and are born with features of adult-like intestine.
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| Overall design |
To assess the function of the gene Prdm1 (Blimp) on postnatal day 7 intestinal epithelium, VillinCre-Blimpflox and control (VillinCre-Blimpwt or Cre-Blimpflox) mice were generated. Mice were sacrificed at day 7 postnatal, and pieces of whole mid-intestine were taken for analysis.
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| Contributor(s) |
Muncan V, Heijmans J |
| Citation(s) |
21878906 |
| Submission date |
Jul 11, 2011 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Jarom Heijmans |
| E-mail(s) |
j.heijmans@amc.nl
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| Organization name |
Academic Medical Center
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| Department |
Tytgat Institute for liver and intestinal research
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| Lab |
van den Brink Group
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| Street address |
Meibergdreef 69-71
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| City |
Amsterdam |
| ZIP/Postal code |
1105 BK |
| Country |
Netherlands |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (16)
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| GSM758310 |
intestine, BlimpWT, rep4 |
| GSM758311 |
intestine, BlimpWT, rep5 |
| GSM758312 |
intestine, BlimpWT, rep6 |
| GSM758313 |
intestine, BlimpWT, rep7 |
| GSM758314 |
intestine, BlimpWT, rep8 |
| GSM758315 |
intestine, BlimpKO, rep1 |
| GSM758316 |
intestine, BlimpKO, rep2 |
| GSM758317 |
intestine, BlimpKO, rep3 |
| GSM758318 |
intestine, BlimpKO, rep4 |
| GSM758319 |
intestine, BlimpKO, rep5 |
| GSM758320 |
intestine, BlimpKO, rep6 |
| GSM758321 |
intestine, BlimpKO, rep7 |
| GSM758322 |
intestine, BlimpKO, rep8 |
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| Relations |
| BioProject |
PRJNA144477 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE30556_RAW.tar |
3.1 Mb |
(http)(custom) |
TAR |
| GSE30556_non-normalized.txt.gz |
1.6 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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