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Series GSE30556 Query DataSets for GSE30556
Status Public on Jul 18, 2011
Title VillinCre-Blimpflox mice postpartum day 7
Organism Mus musculus
Experiment type Expression profiling by array
Summary In many mammalian species, the intestinal epithelium is immature at birth. During the suckling to weaning transition, the intestine matures. This developmental transition is the result of a genetic program that is intrinsic to the gut and independent of luminal content, but its regulators have not been identified. We investigated the function of the transcriptional repressor Blimp-1 using mice with intestine-specific ablation of Blimp-1. Deletion of Blimp-1 results in growth retardation and excess neonatal mortality. Mutant mice lack all typical epithelial features of the suckling period and are born with features of adult-like intestine.
 
Overall design To assess the function of the gene Prdm1 (Blimp) on postnatal day 7 intestinal epithelium, VillinCre-Blimpflox and control (VillinCre-Blimpwt or Cre-Blimpflox) mice were generated. Mice were sacrificed at day 7 postnatal, and pieces of whole mid-intestine were taken for analysis.
 
Contributor(s) Muncan V, Heijmans J
Citation(s) 21878906
Submission date Jul 11, 2011
Last update date Jun 14, 2018
Contact name Jarom Heijmans
E-mail(s) j.heijmans@amc.nl
Organization name Academic Medical Center
Department Tytgat Institute for liver and intestinal research
Lab van den Brink Group
Street address Meibergdreef 69-71
City Amsterdam
ZIP/Postal code 1105 BK
Country Netherlands
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (16)
GSM758307 intestine, BlimpWT, rep1
GSM758308 intestine, BlimpWT, rep2
GSM758309 intestine, BlimpWT, rep3
Relations
BioProject PRJNA144477

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE30556_RAW.tar 3.1 Mb (http)(custom) TAR
GSE30556_non-normalized.txt.gz 1.6 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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