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| Status |
Public on Aug 03, 2011 |
| Title |
Transcriptome Analysis of Human Diabetic Kidney Disease (Control Glomeruli vs. Control Tubuli) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We identified 1,700 differentially expressed probesets in DKD glomeruli and 1,831 in diabetic tubuli; 330 probesets were commonly differentially expressed in both compartments. The canonical complement signaling pathway was determined to be statistically differentially regulated in both DKD glomeruli and tubuli and was associated with increased glomerulosclerosis even in an additional set of DKD samples.
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| Overall design |
Affymetrix expression arrays were used to identify differentially regulated transcripts in 44 microdissected human kidney samples. Stringent statistical analysis using the Benjamini_Hochberg corrected 2-tailed t-test was used to identify differentially expressed transcripts in control and diseased glomeruli and tubuli.
This Series includes control glomeruli and tubuli samples.
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| Contributor(s) |
Park AS, Mohtat D, Thomas DB, Woroniecka K, Susztak K |
| Citation(s) |
21752957 |
| Submission date |
Jul 11, 2011 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Karolina Woroniecka |
| E-mail(s) |
kworonie@gmail.com
|
| Organization name |
AECOM
|
| Lab |
Susztak
|
| Street address |
1300 Morris Park Ave
|
| City |
Bronx |
| State/province |
NY |
| ZIP/Postal code |
10461 |
| Country |
USA |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (25)
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| This SubSeries is part of SuperSeries: |
| GSE30122 |
Transcriptome Analysis of Human Diabetic Kidney Disease |
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| Relations |
| BioProject |
PRJNA154765 |
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