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Status |
Public on Jul 14, 2011 |
Title |
Attenuation of early atherogenesis in LDLR-KO mice by proteasome inhibition |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
To get further insights into the processes leading to attenuation of early stage atherosclerosis in the bortezomib treated LDLR-KO mice, microarray profiling of gene expression was performed on RNA taken from whole aortae of bortezomib treated LDLR-KO and sham- treated LDLR-KO mice fed a Western diet for 6 weeks and compared the changes in gene expression in both groups to non-atherosclerotic CD animals.
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Overall design |
Male 10-week-old LDLR-KO mice (B6.129S7-Ldlrtm1Her/J; JAX Mice, Boston) were fed a Western-type diet for 6 weeks ad libitum and received intraperitoneal injections of bortezomib (50 µg/kg body weight; WD+Bor) or saline (WD) twice weekly (n = 4). Mice that were fed normal diet served as chow diet control (CD; n = 4). Gene expression in aortic tissue was measured. Two independent experiments were performed.
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Contributor(s) |
Ludwig A, Wilck N |
Citation(s) |
22516063 |
Submission date |
Jul 13, 2011 |
Last update date |
May 10, 2018 |
Contact name |
Antje Ludwig |
E-mail(s) |
antje.ludwig@charite.de
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Organization name |
Charité Universitätsmedizin Berlin
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Department |
Kardiologie
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Lab |
Forschungslabor
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Street address |
Ziegelstr. 5-9
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City |
Berlin |
ZIP/Postal code |
10117 |
Country |
Germany |
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Platforms (1) |
GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
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Samples (6)
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Relations |
BioProject |
PRJNA144633 |