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Series GSE31096 Query DataSets for GSE31096
Status Public on Aug 02, 2011
Title Genome-wide identification of Bcl11b gene targets
Organism Mus musculus
Experiment type Expression profiling by array
Summary B-cell leukemia/lymphoma 11B (Bcl11b) is a transcription factor showing predominant expression in the striatum. To date, there are no known gene targets of Bcl11b in the nervous system. Here, we define targets for Bcl11b in striatal cells by performing genome-wide expression profiling. Transcriptome-wide analysis revealed that 694 genes were significantly altered in striatal cells over-expressing Bcl11b, including genes showing striatal-enriched expression similar to Bcl11b. Functional analysis on the gene target list identified significant association of Bcl11b to brain-derived neurotrophic factor/neurotrophin signaling. These data implicate Bcl11b as a novel regulator of the BDNF signaling pathway, which is disrupted in many neurological disorders.
 
Overall design n=4 wt STHdh striatal cells and n=4 Bcl11b-transfected STHdh striatal cells
 
Contributor(s) Tang B, Schaffer L, Head SR, Thomas EA
Citation(s) 21912641
Submission date Aug 01, 2011
Last update date Jun 14, 2018
Contact name Elizabeth A. Thomas
Organization name The Scripps Research Institute
Department Molecular Biology
Street address 10550 N. Torrey Pines Rd
City La Jolla
State/province CA
ZIP/Postal code 92037
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (8)
GSM769940 PcDNA3.1-1
GSM769941 PcDNA3.1-2
GSM769942 PcDNA3.1-3
Relations
BioProject PRJNA144713

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE31096_RAW.tar 3.1 Mb (http)(custom) TAR
GSE31096_non-normalized.txt.gz 1.5 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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