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Series GSE31207 Query DataSets for GSE31207
Status Public on Jul 28, 2014
Title The Sex-Specific Changes in Gene Expression and Behavior Induced by Chronic Toxoplasma Infection in Mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary The goal of this study was to identify the neural systems that underlie the behavorial changes in intermediate hosts of Toxoplasma gondii. Using a mouse whole genome microarray, we analyzed gene expression in the frontal cortex during the latent stages of infection. We found marked sex-dependent effects on gene transcription in mice. In female mice, Toxoplasma infection altered the expression of genes involved in the development of the forebrain, neurogenesis, sensory and motor coordination. In male mice, infection led mainly to modulation of genes associated with olfaction. Our results indicate that the gender of the host plays a major role in determining variable brain changes following Toxoplasma infection.
Overall design Male and female BALB/c mice (infected female: n=5; infected male: n=5; female control: n=5; male control: n=4) were used in this study. They were sacrificed approximately 6 month post infection and the frontal cortices harvested. RNA transcript levels were quantified by microarray analyses using Illumina Mouse Ref-8 v2.0 Expression BeadChips.
Contributor(s) Xiao J, Kannan G, Jones-Brando L, Brannock C, Krasnova IN, Lud Cadet J, Pletnikov M, Yolken RH
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Submission date Aug 04, 2011
Last update date Jun 14, 2018
Contact name JC xiao
Organization name Johns Hopkins University
Street address 600 N. Wolfe Street, Blalock 1109
City Baltimore
State/province MD
ZIP/Postal code 21287
Country USA
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (19)
GSM773509 frontal cortices_male control_6 month_rep1
GSM773510 frontal cortices_male control_6 month_rep2
GSM773511 frontal cortices_male control_6 month_rep3
BioProject PRJNA145981

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Supplementary file Size Download File type/resource
GSE31207_RAW.tar 3.1 Mb (http)(custom) TAR
GSE31207_non-normalized.txt.gz 1.2 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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