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Series GSE31251 Query DataSets for GSE31251
Status Public on Sep 21, 2011
Title Expression data from mouse heart deficient of HDAC3
Organism Mus musculus
Experiment type Expression profiling by array
Summary Gene expression changes in the heart of MCH3-KO mouse (HDAC3 f/f, Muscle Creatine Kinase-Cre) versus control WT mouse (HDAC3 f/f).
Histone deacetylases (HDACs) play important roles in cardiac development and function. We show here that mice deficient of HDAC3 in heart and skeletabl muscle are relatively normal on normal chow, but develop hypertrophic cardiomyopathy and heart failure that leads to death on high-fat diet. This microarray experiment is to explore the underlying molecular mechanism.
 
Overall design Hearts from 6-weeks old WT and MCH3-KO C57BL/6 mice (n=4 in each group, male) on normal chow were subjected to RNA extraction and Affymetrix Mouse Gene 1.0ST analysis.
 
Contributor(s) Sun Z, Lazar MA
Citation(s) 21808063
Submission date Aug 08, 2011
Last update date Mar 04, 2019
Contact name Zheng Sun
E-mail(s) zheng.sun@bcm.edu
Organization name Baylor College of Medicine
Street address 1 Baylor Plaza
City Houston
State/province TX
ZIP/Postal code 77030
Country USA
 
Platforms (1)
GPL6246 [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
Samples (8)
GSM774636 WT mouse heart at 6-weeks old, biological rep1
GSM774637 WT mouse heart at 6-weeks old, biological rep2
GSM774638 WT mouse heart at 6-weeks old, biological rep3
Relations
BioProject PRJNA146063

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Supplementary file Size Download File type/resource
GSE31251_RAW.tar 31.2 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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