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Series GSE31526 Query DataSets for GSE31526
Status Public on Apr 10, 2012
Title Exacerbated T cell lymphoma in NOD.Stat5bTg mice is caused by selective activation of Stat5b in CD8+ thymocytes and can be prevented by inhibition of the Stat5b signaling pathway with chemoprevention agents
Organism Mus musculus
Experiment type Expression profiling by array
Summary This study demonstrated that genetic background is critical to the STAT5B-mediated lymphomagenesis probably through regulation of STAT5B activation, which results in the alteration of many tumorigenic genes. Chemopreventive compounds that can reduce STAT5B phosphorylation and/or the STAT5B signaling pathway can efficiently block lymphomagenesis, demonstrating that the NOD.Stat5bTg mouse is an excellent model for testing novel chemopreventive strategies.
 
Overall design To elucidate the molecular mechanism underlying the activation of Stat5b upon lymphoma onset, we profiled gene expression in thymocytes of NOD.Stat5b mice, Gene expression was analyzed with the Illumina's MouseRef-8 v2.0 Expression beadchips
 
Contributor(s) Chen B, Yi B, Mao R, Liu H, Wang J, Guo B, Peiper S, Leonard WJ, She J
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Submission date Aug 18, 2011
Last update date Jun 14, 2018
Contact name Jin-Xiong She
E-mail(s) jshe@gru.edu
Phone 706-721-3410
Fax 706-721-3688
URL http://www.cbgm.mcg.edu/
Organization name Medical College of Georgia
Department Center for Biotechnology and Genomic Medicine
Street address 1120 15th Street, CA4124
City Augusta
State/province GA
ZIP/Postal code 30912-2400
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (15)
GSM782632 NOD 8P
GSM782633 NOD 9P
GSM782634 NOD 11P
Relations
BioProject PRJNA145519

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE31526_RAW.tar 3.1 Mb (http)(custom) TAR
GSE31526_non-normalized.txt.gz 3.1 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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