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Series GSE31560 Query DataSets for GSE31560
Status Public on Nov 01, 2011
Title Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS
Organism Mus musculus
Experiment type Expression profiling by array
Summary Forkhead box protein P1 (Foxp1), a transcription factor showing highly enriched expression in the striatum, has been implicated in CNS development, but its role in the mature brain is unknown. In order to ascertain functional roles for Foxp1 in the CNS, we have identified gene targets for Foxp1 in vitro using gene expression microarrays and chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) assays. Transcriptome-wide analysis of Foxp1-transfected striatal cells revealed widespread expression changes of genes related to immune signaling, cancer, transcriptional regulation, and a curated Huntington’s disease (HD) signaling pathway. Integrating the microarray expression dataset with Foxp1 binding sequences determined from ChIP-seq analysis resulted in 75 direct targets of Foxp1, which included Foxp1 itself, which were also related to immune processes and the category “genetic disorder”. These findings demonstrate that Foxp1 is a primary transcriptional repressor of immunological-related gene expression in striatal cells.
 
Overall design n=3 wt STHdh striatal cells and n=3 Foxp1-transfected STHdh striatal cells
 
Contributor(s) Tang B, Schaffer L, Head SR, Thomas EA
Citation(s) 22492998
Submission date Aug 22, 2011
Last update date Jun 14, 2018
Contact name Elizabeth A. Thomas
Organization name The Scripps Research Institute
Department Molecular Biology
Street address 10550 N. Torrey Pines Rd
City La Jolla
State/province CA
ZIP/Postal code 92037
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (6)
GSM783274 PcDNA-1
GSM783275 PcDNA-2
GSM783276 PcDNA-3
Relations
BioProject PRJNA145685

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE31560_RAW.tar 3.1 Mb (http)(custom) TAR
GSE31560_non-normalized_data.txt.gz 1.2 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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