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| Status |
Public on Aug 27, 2011 |
| Title |
MAP Kinase Phosphatase-1 Modulates Regional Effects of Injurious Mechanical Ventilation in Rodent Lungs |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
Scientific knowledge on the subjects: Injurious mechanical ventilation amplifies acute lung injury in a heterogeneous and regional fashion but the molecular mechanisms underlying regional lung injury and the protective effects of prone positioning are unclear.
Regionally injurious ventilation is associated with discrete differential lung transcriptomic changes. Ventilating in the prone, compared with the supine position abrogates regional injury by depressing MKP-1.
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| Overall design |
Adult rats were ventilated with high (18 mL/Kg, PEEP 0) tidal volume (Vt) in supine or prone position. Non ventilated rats were used as controls. Dorsal-caudal lung mRNA was analyzed by microarray.
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| Contributor(s) |
Park MS, He Q, Edwards MG, Sergew A, Riches DW, Albert RK, Douglas IS |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 26, 2011 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Michael Edwards |
| E-mail(s) |
michael.edwards@ucdenver.edu
|
| Phone |
303-724-6054
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| Organization name |
UC Denver
|
| Department |
Pulmonary
|
| Street address |
12700 East 19th Avenue, Box C272
|
| City |
Aurora |
| State/province |
CO |
| ZIP/Postal code |
80045 |
| Country |
USA |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA145377 |
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