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Status |
Public on Sep 02, 2011 |
Title |
Genome-wide maps of TCF7L1 binding during early adipogenesis |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
Here we show through genome-wide binding studies that transcription factor 7-like 1 (TCF7L1) represses structure-related genes during adipogenesis. Intriguingly, TCF7L1 is induced in a cell contact-dependent manner by confluency in preadipocytes and is required for adipocyte differentiation by repressing transcription of cell structure genes. TCF7L1 is also sufficient to bestow adipogenic potential upon non-adipogenic cells. These results implicate TCF7L1 as a novel adipogenic competency factor that uniquely determines adipogenic fate through cell structure organization required for adipocyte gene activation.
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Overall design |
Examination of TCF7L1 binding in preadipocytes treated for 24 hours with adipogenic stimuli.
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Contributor(s) |
Cristancho AG, Lazar MA |
Citation(s) |
21914845 |
Submission date |
Sep 02, 2011 |
Last update date |
May 15, 2019 |
Contact name |
Jonathan Schug |
E-mail(s) |
jschug@pennmedicine.upenn.edu
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Phone |
215 898 0773
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Organization name |
University of Pennsylvania
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Department |
School of Medicine
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Lab |
Next-Generation Sequencing Core
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Street address |
12-156 Smilow Ctr Trans Research
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City |
Philadelphia |
State/province |
Pennsylvania |
ZIP/Postal code |
19104-5160 |
Country |
USA |
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Platforms (1) |
GPL9185 |
Illumina Genome Analyzer (Mus musculus) |
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Samples (1) |
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Relations |
SRA |
SRP008061 |
BioProject |
PRJNA145073 |