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Series GSE31867 Query DataSets for GSE31867
Status Public on Sep 02, 2011
Title Genome-wide maps of TCF7L1 binding during early adipogenesis
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Here we show through genome-wide binding studies that transcription factor 7-like 1 (TCF7L1) represses structure-related genes during adipogenesis. Intriguingly, TCF7L1 is induced in a cell contact-dependent manner by confluency in preadipocytes and is required for adipocyte differentiation by repressing transcription of cell structure genes. TCF7L1 is also sufficient to bestow adipogenic potential upon non-adipogenic cells. These results implicate TCF7L1 as a novel adipogenic competency factor that uniquely determines adipogenic fate through cell structure organization required for adipocyte gene activation.
 
Overall design Examination of TCF7L1 binding in preadipocytes treated for 24 hours with adipogenic stimuli.
 
Contributor(s) Cristancho AG, Lazar MA
Citation(s) 21914845
Submission date Sep 02, 2011
Last update date May 15, 2019
Contact name Jonathan Schug
E-mail(s) jschug@pennmedicine.upenn.edu
Phone 215 898 0773
Organization name University of Pennsylvania
Department School of Medicine
Lab Next-Generation Sequencing Core
Street address 12-156 Smilow Ctr Trans Research
City Philadelphia
State/province Pennsylvania
ZIP/Postal code 19104-5160
Country USA
 
Platforms (1)
GPL9185 Illumina Genome Analyzer (Mus musculus)
Samples (1)
GSM790410 TCF7L1_ChIP_seq
Relations
SRA SRP008061
BioProject PRJNA145073

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE31867_RAW.tar 40.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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