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| Status |
Public on Jul 03, 2013 |
| Title |
Huh7 cells exist as a mixed population of cells with distinct patterns of gene methylation |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
A powerful approach to study innate antiviral response is to compare the difference between wild type Huh7 cells, which do not support robust replication of hepatitis C virus (HCV)2, versus certain subclones of Huh7 cells that are permissive for HCV replication. We generated two permissive cell lines and two independent non-permissive subclone from Huh7 cells. We compared the global methylation pattern of these different cells and find that Huh7 cells exist as a heterogeneous population of cells with distinct patterns of gene methylation.
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| |
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| Overall design |
Comparison of Huh7, HRP1, HRP4, Huh7-pNeo1 and Huh7-pNeo2 cells.
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| |
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| Contributor(s) |
Chen Q |
| Citation(s) |
23115279 |
| Submission date |
Sep 07, 2011 |
| Last update date |
Jul 24, 2013 |
| Contact name |
Qiuyue Chen |
| E-mail(s) |
chenqiuyue23@gmail.com
|
| Phone |
(214) 648-3078
|
| Organization name |
UT Southwestern Medical Center
|
| Department |
Molecular Genetics
|
| Lab |
Jin Ye
|
| Street address |
5323 Harry Hines Blvd.
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| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75390 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL14546 |
NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1] |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE31962 |
HCV Replication: permissive and non-permissive cells |
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| Relations |
| BioProject |
PRJNA155279 |
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