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Series GSE32018 Query DataSets for GSE32018
Status Public on Oct 17, 2011
Title Gene-expression profile in a series of non-Hodgkin lymphoma (NHL) patients
Organism Homo sapiens
Experiment type Expression profiling by array
Summary PIM serine/threonine kinases are overexpressed, translocated or amplified in multiple B-cell lymphoma types. We have explored the frequency and relevance of PIM expression in different B-cell lymphoma types, and investigated whether PIM inhibition could be a rational therapeutic approach. Increased expression of PIM2 was detected in subsets of mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBLC), follicular lymphoma (FL), marginal zone lymphoma-MALT type (MZL-MALT), chronic lymphocytic leukemia (CLL) and nodal marginal zone lymphoma (NMZL) cases. Increased PIM2 protein expression was associated with an aggressive clinical course in ABC-DLBCL patients. Pharmacological and genetic inhibition of PIM2 revealed p4E-BP1(Thr37/46) and p4E-BP1(Ser65) as molecular biomarkers characteristic of PIM2 activity, and indicated the involvement of PIM2 kinase in regulating mTORC1. The simultaneous genetic inhibition of all three PIM kinases induced changes in apoptosis and cell cycle. In conclusion, we show that PIM2 kinase inhibition is a rational approach in DLBCL treatment, identify appropriate biomarkers for pharmacodynamic studies, and provide a new marker for patient stratification.
 
Overall design Gene-expression profiling was conducted in a series of 114 B-cell non-Hodgkin lymphoma patients (DLBCL, FL, MALT, MCL, CLL and NMZL). Seven freshly frozen lymph nodes and six freshly frozen reactive tonsils were used as controls.
 
Contributor(s) Gómez-Abad C, Rodríguez ME, Piris MA
Citation(s) 21937691
Submission date Sep 09, 2011
Last update date Jan 23, 2019
Contact name Cristina Gomez-Abad
E-mail(s) crisytina@gmail.com
Organization name CNIO
Department Molecular Pathology Program
Lab Lymphoma's Group
Street address Melchor Fernández Almagro, 3
City Madrid
ZIP/Postal code 28029
Country Spain
 
Platforms (1)
GPL6480 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)
Samples (127)
GSM793379 Diffuse Large B cell Lymphoma (DLBCL_60528)
GSM793380 Follicular Lymphoma (FL_31266)
GSM793381 Follicular Lymphoma (FL_11094)
Relations
BioProject PRJNA147523

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE32018_RAW.tar 1.9 Gb (http)(custom) TAR (of TXT)
Processed data included within Sample table
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