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| Status |
Public on Oct 01, 2011 |
| Title |
Mammary Tissue: Wild type mammary glands vs IGF-IR induced mammary tumors vs IGF-IR independent tumors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Molecular profiling was used to classify mammary tumors that develop in MTB-IGFIR transgenic mice. It was determined that the primary mammary tumors (PMT), which develop due to elevated expression of the type I insulin-like growth factor receptor (IGF-IR) in mammary epithelial cells, most closely resemble murine tumors with basal-like or mixed gene expression profiles and with human basal-like breast cancers. Downregulation of IGF-IR transgene in MTB-IGFIR tumor-bearing mice leads to the regression of most of the tumors followed by tumor re-appearance in some of the mice. These tumors that re-appear following IGF-IR transgene downregulation do not express the IGF-IR transgene and cluster with murine mammary tumors that express a mesenchymal gene expression profile and with human claudin-low breast cancers. Therefore, IGF-IR overexpression in murine mammary epithelial cells induces mammary tumors with primarily basal-like characteristics while tumors that develop following IGF-IR downregulation express a gene signature that most closely resembles human claudin-low breast tumors.
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| Overall design |
Three conditions: 8 wild type (WT) mammary glands, 11 primary mammary tumor (PMT) samples, 9 recurrent spindle tumor (RST) samples, each sample was hybridized against a universal mouse reference RNA
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| Contributor(s) |
Moorehead RA, Livingstone J |
| Citation(s) |
22020329, 30597648 |
| Submission date |
Sep 15, 2011 |
| Last update date |
Feb 27, 2019 |
| Contact name |
Roger A Moorehead |
| E-mail(s) |
rmoorehe@uoguelph.ca
|
| Phone |
519-824-4120 (54950)
|
| Fax |
519-767-1450
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| Organization name |
University of Guelph
|
| Department |
Department of Biomedical Sciences
|
| Street address |
50 Stone Rd East
|
| City |
Guelph |
| State/province |
Ontario |
| ZIP/Postal code |
N1G2W1 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (28)
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| Relations |
| BioProject |
PRJNA147647 |
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