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Series GSE32226 Query DataSets for GSE32226
Status Public on Sep 15, 2012
Title Expression data for pharmacogenomics antiplatelet therapy
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Antiplatelet therapy is the most important treatment to reduce the risk of developing recurrent thrombosis, and to prevent progression to a complete occlusion of coronary arterial disease (CAD) patients after percutaneous coronary intervention
Aim of study was to investigate the relationship between response to antiplatelet drugs and global mRNA gene expression in peripheral blood cells (PBC) in patients with coronary arterial disease (CAD)
 
Overall design All patients were treated crhonically with acetylsalicylic acid (ASA) (100 mg/day) and clopidogrel (75 mg/day). Blood samples were drown before PCI to evaluate platelet reactivity by VerifyNow® ASA and P2Y12 assays and mRNA expression was measured by Affymetrix GeneChip Human Exon 1.0 ST array.
 
Contributor(s) Luchessi AD, Silbiger VN, Hirata RD, Lima-Neto LG, Cavichioli D, Iñiguez A, Bravo MS, Bastos G, Sousa AG, Brión M, Carracedo A, Hirata MH
Citation(s) 23832067
Submission date Sep 19, 2011
Last update date Aug 18, 2020
Contact name Andre Ducati Luchessi
E-mail(s) adluchessi@usp.br
Phone 551130913660
Organization name University of Sao Paulo
Street address Av. Prof Lineu Prestes, 580
City Sao Paulo
ZIP/Postal code 05508000
Country Brazil
 
Platforms (1)
GPL5175 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version]
Samples (26)
GSM798636 partial responder clopidogrel and partial responder ASA AMP
GSM798637 partial responder clopidogrel and partial responder ASA AMR
GSM798638 responder clopidogrel and non responder ASA APF
Relations
BioProject PRJNA147205

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Supplementary file Size Download File type/resource
GSE32226_RAW.tar 554.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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