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Series GSE32305 Query DataSets for GSE32305
Status Public on Dec 31, 2011
Title Establishing a set of genes differentially expressed in benign versus malignant adrenocortical cells
Organism Bos taurus
Experiment type Expression profiling by array
Summary Models for tumorigenesis can be made by transforming normal cells with defined genetic elements. This allows us to determine that adrenocortical tumor development and progression follows a multistep model. Morever, we demonstrated that the order of genetic events has a great consequence on the phenotype of the resultant tumor. We performed transcriptomic analysis using cDNA microarrays to identify the molecular signature that might explain the distinctive in vivo phenotypes observed in response to both orders of the mutational events.
 
Overall design Two p53+Ras two pBabe +pLNCX2 (control for the p53+Ras cells), three Ras+p53 and two pLNCX2+pBabe (control for Ras+p53 cells) cell populations were prepared and used for microarray analysis;
 
Citation(s) 22589739
Submission date Sep 22, 2011
Last update date Dec 17, 2012
Contact name Michaƫl Thomas
E-mail(s) michael.thomas@cea.fr
Phone (33)-438-78-44-64
Fax (33)-438-78-50-58
Organization name Inserm U1036
Department iRTSV/BCI
Street address 17 rue des martyrs
City Grenoble
ZIP/Postal code 38054
Country France
 
Platforms (1)
GPL2112 [Bovine] Affymetrix Bovine Genome Array
Samples (9)
GSM800430 Bovine adrenocortical cells transduced with p53 and Ras, biological rep1
GSM800431 Bovine adrenocortical cells transduced with p53 and Ras, biological rep2
GSM800432 Bovine adrenocortical cells transduced with Ras and p53, biological rep1
Relations
BioProject PRJNA146345

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE32305_RAW.tar 20.4 Mb (http)(custom) TAR (of CEL, CHP)
GSE32305_fold_change.txt.gz 179.5 Kb (ftp)(http) TXT
Processed data provided as supplementary file
Processed data included within Sample table
Processed data are available on Series record

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