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| Status |
Public on Apr 06, 2012 |
| Title |
Murine blood monocyte subsets |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Monocytes and their lineage descendants serve as a central defense system against infection and injury but if uncontrolled can also promote an excessive pathological inflammatory response. Therefore a current research goal is to understand how the organism controls the number and function of monocytes and how these variables can be tailored in therapy. Considering the evidence that monocytes are heterogeneous and exist in at least two subsets committed to divergent functions, we investigated whether distinct factors regulate the balance between monocyte subset responses in vivo. Here we investigate the differential expression of mRNA among murine steady-state monocyte subsets.
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| Overall design |
Blood was drawn from healthy C57BL/6 donors. For each biological replicate 1000 monocytes of the Ly-6Chi and Ly-6Clo phenotype were isolated from the blood sample through fluorescence activated cell sorting.
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| Contributor(s) |
Etzrodt M |
| Citation(s) |
22545247 |
| Submission date |
Sep 24, 2011 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Martin Etzrodt |
| E-mail(s) |
ETZRODT.MARTIN@MGH.HARVARD.EDU
|
| Phone |
(617) 643-0500
|
| Fax |
(617) 643-6133
|
| URL |
http://csb.mgh.harvard.edu/pittet
|
| Organization name |
Massachusetts General Hospital
|
| Department |
Center for Systems Biology
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| Lab |
Pittet Lab
|
| Street address |
185 Cambridge Street
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02114 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE32392 |
Regulation of Monocyte Functional Heterogeneity by miR-146a |
|
| Relations |
| BioProject |
PRJNA154529 |
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