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Series GSE32372 Query DataSets for GSE32372
Status Public on Feb 07, 2012
Title Innate response activator B cells are sentinels that guard against polymicrobial sepsis
Organism Mus musculus
Experiment type Expression profiling by array
Summary Innate immunity is fundamental to recognition and clearance of bacterial infection. The relevant cells and molecules that orchestrate an effective response, however, remain incompletely understood. Here we describe a previously unknown population of B cells, which we have named innate response activator (IRA) B cells that recognize bacteria directly through TLR-4-MyD88 and protect against polymicrobial sepsis.
IRA-B cells have a unique IgM high CD23 low CD43 + CD93+ GM-CSF+ signature, develop and diverge from B1a B cells, require BAFFR, and adhere to tissue via VLA-4 and LFA-1.
 
Overall design B cell subsets are sorted from the spleen and peritoneum of C57BL/6 mice that were given intraperitoneal injections of LPS once daily for four days.
 
Contributor(s) Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Figueiredo J, Iwamoto Y, Gorbatov R, Mouded M, Pittet M, Nahrendorf M, Weissleder R, Swirski FK
Citation(s) 22245738
Submission date Sep 26, 2011
Last update date Jun 14, 2018
Contact name Martin Etzrodt
E-mail(s) fswirski@mgh.harvard.edu, etzrodt.martin@mgh.harvard.edu
URL http://csb.mgh.harvard.edu/filip_swirski
Organization name Massachusetts General Hospital
Department Center for Systems Biology
Lab Swirski
Street address 185 Cambridge St
City Cambridge
State/province MA
ZIP/Postal code 02114
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (21)
GSM801437 splenic follicular B cells 1
GSM801438 splenic follicular B cells 2
GSM801439 splenic follicular B cells 3
Relations
BioProject PRJNA147973

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE32372_RAW.tar 3.1 Mb (http)(custom) TAR
GSE32372_non-normalized_data.txt.gz 3.4 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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