|
| Status |
Public on Nov 30, 2011 |
| Title |
miRNA profiling in osteosarcoma: a cell line based approach with correlation to gene expression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We found various genes involved in differentiation (RGMB, LRRC17), cell cycle control (Cyclin E1) and apoptosis (LIMA1, CAMK2N1) were found to be deregulated in osteosarcoma cell lines, most likely due to altered miRNA expression patterns.
Our findings indicate a crucial impact of deregulated miRNAs with consecutive changes in gene expression in osteosarcomas that strongly suggests pathogenetic and potentially therapeutic implications.
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| |
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| Overall design |
We investigated seven well-established osteosarcoma cell lines for genome wide miRNA expression (miRBase version 15.0) and integrated our findings with gene expression
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This represents the mRNA component of the study
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| |
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| Contributor(s) |
Baumhoer D, Zillmer S, Unger K, Rosemann M, Atkinson MJ, Irmler M, Beckers J, Siggelkow H, von Luettichau I, Jundt G, Smida J, Nathrath M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Sep 26, 2011 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Jan Smida |
| E-mail(s) |
smida@helmholtz-muenchen.de
|
| Phone |
00498937813797
|
| Fax |
00498931873381
|
| Organization name |
HelmholtzZentrum
|
| Department |
CCg Osteosarcoma
|
| Lab |
57/129
|
| Street address |
Ingolstaedter Land 1
|
| City |
Neuherberg |
| ZIP/Postal code |
D-85764 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (9)
|
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| Relations |
| BioProject |
PRJNA147947 |
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