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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jun 12, 2012 |
| Title |
Cancer stem cell subpopulations within the CD44high human breast cancer stem cell compartment |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The CD44hi compartment in human breast cancer is enriched in tumor-initiating cells, however the functional heterogeneity within this subpopulation remains poorly defined. From a human breast cancer cell line with a known bi-lineage phenotype we have isolated and cloned two CD44hi populations that exhibited mesenchymal/Basal B and luminal/Basal A features, respectively. Rather than CD44+/CD24-,Basal B (G4) cells, only CD44hi/CD24lo, epithelioid Basal A (A4) cells retained a tumor-initiating capacity in NOG mice, form mammospheres and exhibit resistance to standard chemotherapy.
Microarray data obtained from Affymetrix Human Gene 1.0 ST Array
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| Overall design |
Five replicates of A4 and 5 replicates of G4
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| Contributor(s) |
Leth-Larsen R, Ditzel HJ |
| Citation(s) |
22692575 |
| Submission date |
Sep 28, 2011 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Rikke Leth-Larsen |
| E-mail(s) |
rllarsen@health.sdu.dk
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| Organization name |
University of Southern Denmark
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| Department |
Institute of Molecular Medicine
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| Street address |
JB Winsloewsvej 25
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| City |
Odense |
| ZIP/Postal code |
5000 |
| Country |
Denmark |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA147739 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE32455_RAW.tar |
41.7 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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