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| Status |
Public on Dec 01, 2005 |
| Title |
Gene Expression Profiles with Common Translocations in Acute Myeloid Leukemia (AML) using SAGE |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by SAGE
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| Summary |
SAGE was used to profile gene expression in leukemic myeloid progenitor cells of AML patients with t(8;21), t(15;17), t(9;11) and inv(16).
Keywords: SAGE analysis of gene expression in leukemic myeloid progenitor cells isolated from bone marrow
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| Overall design |
Bone marrow cells from 4 patients with de novo t(9;11), 3 with treatment-related t(9;11), and 5 each with inv(16), t(15;17), t(8;21) were used for the study. Each sample contained at least 75% affected cells with no other chromosome abnormalities at cytogenetic level. Mononuclear cells were purified from bone marrow cells for each sample, and CD15+ myeloid progenitor cells were isolated from these mononuclear cells. Poly A+ RNA were isolated from CD15+ myeloid progenitor cells of each sample for SAGE tag collection.
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| Contributor(s) |
Lee S, Chen J, Zhou G, Shi RZ, Bouffard G, Kocherginsky M, Ge X, Sun M, Jayathilaka N, Kim YC, Emmanuel N, Bohlander S, Minden M, Liu P, Kline J, Ozer O, Larson R, LeBeau M, Green E, Trent J, Karrison T, Wang (Correspondence) SM, Rowley (Correspondence) JD |
| Citation(s) |
16418266 |
| Submission date |
Sep 06, 2005 |
| Last update date |
Sep 20, 2012 |
| Contact name |
San Ming Wang |
| E-mail(s) |
swang1@northwestern.edu
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| Phone |
224-364-7491
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| Fax |
224-364-5003
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| Organization name |
ENH Research Institute, Northwestern University
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| Department |
Center for Functional Genomics
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| Street address |
1001 University Place
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| City |
Evanston |
| State/province |
IL |
| ZIP/Postal code |
60062 |
| Country |
USA |
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| Platforms (1) |
| GPL4 |
SAGE:10:NlaIII:Homo sapiens |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA92907 |
| Supplementary data files not provided |
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