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Series GSE32620 Query DataSets for GSE32620
Status Public on Oct 12, 2011
Title Human keratinocytes stimulated with IL-17C
Organism Homo sapiens
Experiment type Expression profiling by array
Summary IL-17C is important for the pathogenesis of inflammatory diseases such as IBD and psoriasis. We found that IL-17C is highly induced in a murine model of psoriasis. Recent results suggest that IL-17C can target epithelial cells that express both IL-17RA and IL-17RE receptor chains.
Here we identify genes induced in response to IL-17C treatment of human keratinocytes to provide the tools for dissection of the IL-17C signaling pathway.
Overall design Human keratinocytes, HEKn, were incubated in the absence (n = 3) and presence (n = 5) of 500 ng/ml recombinant human IL-17C for 3 and 24 hours. Whole RNA was isolated via RNeasy kit (Qiagen).
Contributor(s) Abbas AR, Pappu R, Ramirez-Carrozzi VR, Hackney JA
Citation(s) 21993848
Submission date Oct 04, 2011
Last update date Jan 23, 2019
Contact name Alex Abbas
Organization name Genentech, Inc.
Department Bioinformatics
Street address 1 DNA Way
City South San Francisco
State/province CA
ZIP/Postal code 94080
Country USA
Platforms (1)
GPL6480 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)
Samples (16)
GSM808633 hIL-17C_3h_Replicate 1
GSM808634 Control_24h_Replicate 1
GSM808635 hIL-17C_24h_Replicate 1
BioProject PRJNA147141

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE32620_RAW.tar 249.8 Mb (http)(custom) TAR (of TXT)
Raw data provided as supplementary file
Processed data included within Sample table

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