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| Status |
Public on Oct 12, 2011 |
| Title |
Human keratinocytes stimulated with IL-17C |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
IL-17C is important for the pathogenesis of inflammatory diseases such as IBD and psoriasis. We found that IL-17C is highly induced in a murine model of psoriasis. Recent results suggest that IL-17C can target epithelial cells that express both IL-17RA and IL-17RE receptor chains.
Here we identify genes induced in response to IL-17C treatment of human keratinocytes to provide the tools for dissection of the IL-17C signaling pathway.
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| Overall design |
Human keratinocytes, HEKn, were incubated in the absence (n = 3) and presence (n = 5) of 500 ng/ml recombinant human IL-17C for 3 and 24 hours. Whole RNA was isolated via RNeasy kit (Qiagen).
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| Contributor(s) |
Abbas AR, Pappu R, Ramirez-Carrozzi VR, Hackney JA |
| Citation(s) |
21993848 |
| Submission date |
Oct 04, 2011 |
| Last update date |
Jan 23, 2019 |
| Contact name |
Alex Abbas |
| E-mail(s) |
abbas@gene.com
|
| Organization name |
Genentech, Inc.
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| Department |
Bioinformatics
|
| Street address |
1 DNA Way
|
| City |
South San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94080 |
| Country |
USA |
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| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA147141 |
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