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Series GSE327 Query DataSets for GSE327
Status Public on Mar 05, 2003
Title Evolution of gene expression in the Drosophila melanogaster subgroup
Platform organism Drosophila melanogaster
Sample organisms Drosophila melanogaster; Drosophila simulans; Drosophila yakuba
Experiment type Expression profiling by array
Summary Little is known about broad patterns of variation and evolution of gene expression during any developmental process. Here we investigate variation in genome-wide gene expression among Drosophila simulans, Drosophila yakuba and four strains of Drosophila melanogaster during a major developmental transition-the start of metamorphosis. Differences in gene activity between these lineages follow a phylogenetic pattern, and 27% of all of the genes in these genomes differ in their developmental gene expression between at least two strains or species. We identify, on a gene-by-gene basis, the evolutionary forces that shape this variation and show that, both within the transcriptional network that controls metamorphosis and across the whole genome, the expression changes of transcription factor genes are relatively stable, whereas those of their downstream targets are more likely to have evolved. Our results demonstrate extensive evolution of developmental gene expression among closely related species.
Keywords: other
 
 
Contributor(s) Rifkin SA, Kim J, White KP
Citation(s) 12548287
Submission date Mar 04, 2003
Last update date Jun 08, 2016
Contact name Scott A Rifkin
Phone 617-496-5540
URL http://kim.bio.upenn.edu/~scott/
Organization name Harvard University
Department OEB
Lab Hartl Lab
Street address 16 Divinity Ave
City Cambridge
State/province MA
ZIP/Postal code 02138
Country USA
 
Platforms (2)
GPL227 DrosophilaWhiteLabJuly2001
GPL228 DrosophilaWhiteLabNov2001
Samples (26)
GSM3345 Drosophila yakuba array 1
GSM3346 Drosophila yakuba array 2
GSM3347 Drosophila yakuba array 3
Relations
BioProject PRJNA85531

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