|
| Status |
Public on Jan 18, 2013 |
| Title |
miRNA expression profiling in squamous cell carcinoma (SCC) |
| Platform organism |
synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
Despite its prevalence, the molecular basis of squamous cell carcinoma (SCC) remains poorly understood. We recently identified the developmental transcription factor Grhl3 as a potent tumor suppressor of SCC, and demonstrated that targeting of Grhl3 by a miR-21-dependent proto-oncogenic network underpins SCC in humans. Reduced levels of GRHL3 and its target gene PTEN are evident in human skin, and head and neck SCC, associated with increased expression of miR-21, which targets both tumor suppressors. Our data defines the miR-21-GRHL3-PTEN-axis as a critical tumor suppressor pathway in SCC.
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| |
|
| Overall design |
Total RNA was isolated from two SCC primary tissue samples and their matched normal skin controls.
|
| |
|
| Contributor(s) |
Darido C |
| Citation(s) |
22094257 |
| Submission date |
Oct 11, 2011 |
| Last update date |
May 02, 2017 |
| Contact name |
Charbel Darido |
| E-mail(s) |
charbel.darido@monash.edu
|
| Organization name |
Monash University
|
| Department |
Medicine
|
| Lab |
Jane
|
| Street address |
99 Commercial road
|
| City |
Melbourne |
| State/province |
Vic |
| ZIP/Postal code |
3004 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL8786 |
[miRNA-1] Affymetrix Multispecies miRNA-1 Array |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA146555 |
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