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Series GSE33157 Query DataSets for GSE33157
Status Public on Dec 09, 2011
Title Sarcolipin is a potential biomarker for dystrophy and is involved in inflammatory processes in skeletal muscles
Organism Mus musculus
Experiment type Expression profiling by array
Summary Myopathies and muscular dystrophies are devastating diseases sharing characteristic symp-toms. Little is known about common aetiopathology and biomarkers are rare. We studied skeletal muscle gene expression in mouse models of myopathies. As dystrophic processes in muscles are characterised by inflammatory processes, we expanded our analy-sis on a rat model of sepsis. We find 25 commonly dysregulated genes. Sarcolipin was upregulated most, exhibiting in-creased protein levels in different muscles as well as in rats treated with an inflammatory agent. Upregulation strongly correlated with disease status. Our findings suggest Sarcolipin as a potential biomarker and imply a new function in inflam-matory response.
 
Overall design Comparison of the expression profile of quadriceps in 2 B6C3Fe a/a-Ttnmdm/J mice with Titin-mutation versus the expression profile of 2 mice without the mutation in Titin [Ttn].
 
Contributor(s) Kohl CH, Sticht C, Tsagogiorgas C, Labeit D, Witt CC
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Submission date Oct 21, 2011
Last update date Jun 21, 2012
Contact name Carsten Sticht
Organization name University Heidelberg
Department ZMF
Street address Theodor-Kutzer-Ufer
City Mannheim
ZIP/Postal code 68169
Country Germany
 
Platforms (1)
GPL14661 [Mouse430_2_Mm_EntrezG] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Brainarray Version 13]
Samples (4)
GSM821062 mdm 325 Ttn+
GSM821063 mdm 326 Ttn+
GSM821064 mdm 328 Ttn-
Relations
BioProject PRJNA149181

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE33157_RAW.tar 13.9 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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