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Series GSE33224 Query DataSets for GSE33224
Status Public on Jul 31, 2013
Title Protein coding gene expression profile of dasatinib-treated chronic myeloid leukemia patients with resistance to imatinib
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Dasatinib has demonstrated efficacy in patients with chronic-phase chronic myeloid leukemia (CML) who had resistance or intolerance to imatinib. However, some patients also develop resistance or intolerance to dasatinib. To identify potential molecular pathways involved in primary resistance to dasatinib in CML, we analyzed gene expression profiles of mononuclear cells of 7 imatinib-resistant patients, collected before and after 1-year dasatinib treatment. Large-scale gene expression was measured with Agilent microarrays covering protein-coding genes and long (>200 nt) noncoding RNAs (lncRNAs). Sets of genes and lncRNAs significantly differentially expressed (>1.5 fold-change; q value ≤10%) were identified. Ingenuity Pathway Analysis pointed to a number of functions, canonical pathways and gene networks that were significantly enriched with differentially expressed genes. In addition to protein-coding genes, lncRNAs have been recently implicated in pathways leading to tumorigenesis. Our data point to new possible regulatory elements involved in dasatinib resistance in CML.
 
Overall design Dasatinib pre-treatment and 1-yr post-treatment samples from 3 responders (R) or 4 non-responders (NR) chronic myeloid leukemia (CML) patients were investigated. We analyzed expression of Pre-treatment R vs. Pre-treatment NR; Pre-treatment R vs. Post-treatment NR; Pre-treatment NR vs. Post-treatment NR.
 
Contributor(s) Silveira RA, Fachel AA, Moreira YB, De Souza CA, Costa FF, Verjovski-Almeida S, Pagnano KB
Citation(s) 23676950
Submission date Oct 25, 2011
Last update date Feb 22, 2018
Contact name Angela A. Fachel
E-mail(s) anf2032@med.cornell.edu
Organization name Weill Cornell Medicine
Street address 1300 York Ave
City New York
State/province New York
ZIP/Postal code 10065
Country USA
 
Platforms (1)
GPL4133 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
Samples (28)
GSM821399 Peripheral blood mononuclear cells of 239-Cy3 post-treatment and 128-Cy5 pre-treatment dasatinib non-responder patient
GSM821494 Peripheral blood mononuclear cells of 239-Cy5 post-treatment and 128-Cy3 pre-treatment dasatinib non-responder patient
GSM821512 Peripheral blood mononuclear cells of 205-Cy3 post-treatment and 131-Cy5 pre-treatment dasatinib non-responder patient
This SubSeries is part of SuperSeries:
GSE33290 Gene expression signatures of dasatinib-treated chronic myeloid leukemia patients with resistance to imatinib
Relations
BioProject PRJNA156613

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE33224_251485012777_2007-08-07_505_495_GE2-v5_95_Feb07_1_3.txt.gz 15.2 Mb (ftp)(http) TXT
GSE33224_251485012777_2007-08-07_505_495_GE2-v5_95_Feb07_1_4.txt.gz 15.2 Mb (ftp)(http) TXT
GSE33224_251485013126_2007-07-12_497-513_GE2-v5_95_Feb07_1_1.txt.gz 15.3 Mb (ftp)(http) TXT
GSE33224_251485013126_2007-07-12_497-513_GE2-v5_95_Feb07_1_2.txt.gz 15.3 Mb (ftp)(http) TXT
GSE33224_251485013126_2007-07-12_497-513_GE2-v5_95_Feb07_1_3.txt.gz 15.2 Mb (ftp)(http) TXT
GSE33224_251485013126_2007-07-12_497-513_GE2-v5_95_Feb07_1_4.txt.gz 15.2 Mb (ftp)(http) TXT
GSE33224_251485013127_2007-07-12_509-524_GE2-v5_95_Feb07_1_3.txt.gz 15.3 Mb (ftp)(http) TXT
GSE33224_251485013127_2007-07-12_546-541_GE2-v5_95_Feb07_1_1.txt.gz 15.3 Mb (ftp)(http) TXT
GSE33224_251485013127_2007-07-12_546-541_GE2-v5_95_Feb07_1_2.txt.gz 15.3 Mb (ftp)(http) TXT
GSE33224_251485013127_2007-07-12_546-541_GE2-v5_95_Feb07_1_4.txt.gz 15.3 Mb (ftp)(http) TXT
GSE33224_251485013131_2007-08-07_512_508_GE2-v5_95_Feb07_1_1.txt.gz 15.3 Mb (ftp)(http) TXT
GSE33224_251485013131_2007-08-07_512_508_GE2-v5_95_Feb07_1_2.txt.gz 15.3 Mb (ftp)(http) TXT
GSE33224_251485013131_2007-08-07_512_508_GE2-v5_95_Feb07_1_3.txt.gz 15.3 Mb (ftp)(http) TXT
GSE33224_251485013131_2007-08-07_512_508_GE2-v5_95_Feb07_1_4.txt.gz 15.3 Mb (ftp)(http) TXT
GSE33224_RAW.tar 6.9 Mb (http)(custom) TAR
GSE33224_README_GSM-to-RawDataFile.txt 5.0 Kb (ftp)(http) TXT
Processed data included within Sample table
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