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Series GSE33452 Query DataSets for GSE33452
Status Public on Nov 05, 2011
Title Genome-wide analysis of gene transcription in myocardium of the doxycycline inducible Tafazzin shRNA knockdown mouse model of Barth syndrome
Organism Mus musculus
Experiment type Expression profiling by array
Summary Analysis of the transcriptome of cardiac tissue from mice trangenically engineered with a doxycycline inducible Tafazzin shRNA knockdown to mimic the loss of function of Tafazzin in Barth syndrome. ShRNA induced knockdown mice were compared to wildtype littermates also fed the doxycyline diet. The hypothesis was to investigate adaptive metabolic and compensatory gene transcriptional changes in myocardium of the mouse model of Barth syndrome
 
Overall design Total RNA obtained from 2 month old cardiac tissue from the doxycycline inducible shRNA Tafazzin knockdown mouse model of Barth syndrome compared to wildtype littermates also fed 625 mg/Kg doxycycline diet
 
Contributor(s) Kiebish MA, Gross RW, Han X
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Submission date Nov 03, 2011
Last update date Jun 14, 2018
Contact name Michael Andrew Kiebish
E-mail(s) kiebish@wustl.edu
Phone 314-362-2229
Fax 314-362-1402
Organization name Washington University School of Medicine
Department Internal Medicine
Lab Richard W. Gross
Street address 660 South Euclid Avenue, Campus Box 8020
City Saint Louis
State/province MO
ZIP/Postal code 63110
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (8)
GSM827104 Heart 2 month old WT rep1 (mouse 5980)
GSM827105 Heart 2 month old WT rep2 (mouse 5981)
GSM827106 Heart 2 month old WT rep3 (mouse 5970)
Relations
BioProject PRJNA148713

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE33452_RAW.tar 3.1 Mb (http)(custom) TAR
GSE33452_non-normalized.txt.gz 1.5 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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