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| Status |
Public on Nov 05, 2011 |
| Title |
Genome-wide analysis of gene transcription in myocardium of the doxycycline inducible Tafazzin shRNA knockdown mouse model of Barth syndrome |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of the transcriptome of cardiac tissue from mice trangenically engineered with a doxycycline inducible Tafazzin shRNA knockdown to mimic the loss of function of Tafazzin in Barth syndrome. ShRNA induced knockdown mice were compared to wildtype littermates also fed the doxycyline diet. The hypothesis was to investigate adaptive metabolic and compensatory gene transcriptional changes in myocardium of the mouse model of Barth syndrome
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| Overall design |
Total RNA obtained from 2 month old cardiac tissue from the doxycycline inducible shRNA Tafazzin knockdown mouse model of Barth syndrome compared to wildtype littermates also fed 625 mg/Kg doxycycline diet
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| |
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| Contributor(s) |
Kiebish MA, Gross RW, Han X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 03, 2011 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Michael Andrew Kiebish |
| E-mail(s) |
kiebish@wustl.edu
|
| Phone |
314-362-2229
|
| Fax |
314-362-1402
|
| Organization name |
Washington University School of Medicine
|
| Department |
Internal Medicine
|
| Lab |
Richard W. Gross
|
| Street address |
660 South Euclid Avenue, Campus Box 8020
|
| City |
Saint Louis |
| State/province |
MO |
| ZIP/Postal code |
63110 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
|
| Samples (8)
|
| GSM827104 |
Heart 2 month old WT rep1 (mouse 5980) |
| GSM827105 |
Heart 2 month old WT rep2 (mouse 5981) |
| GSM827106 |
Heart 2 month old WT rep3 (mouse 5970) |
| GSM827107 |
Heart 2 month old WT rep4 (mouse 5971) |
| GSM827108 |
Heart 2 month old Taz KD rep1 (mouse 5972) |
| GSM827109 |
Heart 2 month old Taz KD rep1 (mouse 5973) |
| GSM827110 |
Heart 2 month old Taz KD rep3 (mouse 5974) |
| GSM827111 |
Heart 2 month old Taz KD rep1 (mouse 5975) |
|
| Relations |
| BioProject |
PRJNA148713 |
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