|
| Status |
Public on May 01, 2006 |
| Title |
Effects of metoprolol and nebivolol on gene expresion in human coronary smooth muscle cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Human coronary smooth muscle cells were treated with two different ß-blocker (metoprolol and nebivolol). RNA from three replicates of each, treated and the untreated control group, were isolated and the expression profiles were determined using Affymetrix Human Genechip U133A arrays. Comparisons between the sample groups allow the identification of genes with different expression patterns between the treated and untreated control cells.
Keywords: atherosclerosis, smooth muscle cell, ß-receptor antagonist, inflammation, microarray, nebivolol
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| |
|
| Overall design |
3 replicates of control cells (untreated), 3 replicates of metoprolol treated cells and 3 replicates of nebivolol treated cells were analyzed
|
| |
|
| Contributor(s) |
Sauter G, Wolf SC, Risler T, Jobst J, Brehm BR |
| Citation(s) |
17467819 |
| Submission date |
Sep 23, 2005 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Bernhard R. Brehm |
| E-mail(s) |
bernhard.brehm@onlinehome.de
|
| Phone |
+4970712982711
|
| Fax |
+497071360245
|
| Organization name |
University of Tuebingen
|
| Street address |
Otfried-Mueller-Str. 10
|
| City |
Tuebingen |
| ZIP/Postal code |
72076 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
|
| Samples (9)
|
| GSM75876 |
coronary smooth muscle cells control replicate 1 |
| GSM75877 |
coronary smooth muscle cells control replicate 2 |
| GSM75878 |
coronary smooth muscle cells control replicate 3 |
| GSM75879 |
coronary smooth muscle cells metoprolol replicate 1 |
| GSM75880 |
coronary smooth muscle cells metoprolol replicate 2 |
| GSM75881 |
coronary smooth muscle cells metoprolol replicate 3 |
| GSM75882 |
coronary smooth muscle cells nebivolol replicate 1 |
| GSM75883 |
coronary smooth muscle cells nebivolol replicate 2 |
| GSM75884 |
coronary smooth muscle cells nebivolol replicate 3 |
|
| Relations |
| BioProject |
PRJNA93279 |
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