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| Status |
Public on Mar 01, 2013 |
| Title |
MicroRNA expression profiling of small-intestine neuroendocrine tumors and human neuroendocrine tumor cell lines |
| Platform organism |
synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Small intestinal neuroendocrine tumors (SI-NETs) arise from serotonin-producing enterochromaffin cells. SI-NETs are often well-differentiated tumors and most patients have regional or distant metastases at initial presentation. MicroRNAs (miRs) are post-transcriptional regulators which are important in diverse biological processes and can function as tumor suppressor genes or oncogenes. This study aims to identify an exclusive SI-NETs miR profile that may have a critical role in development, diagnosis, prognosis and progression of these malignancies.
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| Overall design |
Five human NET cell lines, one octreotide-treated CNDT2.5 cells, one microdissected normal enterochromaffin cells, three snap-frozen normal ileum specimens and 15 SI-NET specimens at different stage of malignancy, five primary tumors, five mesentery metastases and five liver metastases, were included in this study. Total RNA was hybridized onto Affymetrix GeneChip® miR arrays for genome-wide profiling. Array data summarization, normalization, and quality control were performed using miRNA QC Tool software.
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| Contributor(s) |
Li S, Martijn C, Essaghir A, Lloyd RV, Demoulin J, Öberg K, Giandomenico V |
| Citation(s) |
23328977 |
| Submission date |
Nov 09, 2011 |
| Last update date |
May 02, 2017 |
| Contact name |
Jean-Baptiste Demoulin |
| Organization name |
Université catholique de Louvain
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| Department |
de Duve Institute
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| Lab |
UCL - MEXP
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| Street address |
av Hippocrate 75, B1.74.05
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| City |
Brussels |
| ZIP/Postal code |
B-1200 |
| Country |
Belgium |
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| Platforms (1) |
| GPL8786 |
[miRNA-1] Affymetrix Multispecies miRNA-1 Array |
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| Samples (25)
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| GSM830094 |
Midgut carinoid primary tumor, P1 |
| GSM830095 |
Midgut carinoid primary tumor, P2 |
| GSM830096 |
Midgut carinoid primary tumor, P3 |
| GSM830097 |
Midgut carinoid primary tumor, P4 |
| GSM830098 |
Midgut carinoid primary tumor, P5 |
| GSM830099 |
Midgut carinoid Mesentary Metastasis, M1 |
| GSM830100 |
Midgut carinoid Mesentary Metastasis, M2 |
| GSM830101 |
Midgut carinoid Mesentary Metastasis, M3 |
| GSM830102 |
Midgut carinoid Mesentary Metastasis, M4 |
| GSM830103 |
Midgut carinoid Mesentary Metastasis, M5 |
| GSM830104 |
Midgut carinoid Liver Metastasis, L1 |
| GSM830105 |
Midgut carinoid Liver Metastasis, L2 |
| GSM830106 |
Midgut carinoid Liver Metastasis, L3 |
| GSM830107 |
Midgut carinoid Liver Metastasis, L4 |
| GSM830108 |
Midgut carinoid Liver Metastasis, L5 |
| GSM830109 |
CNDT |
| GSM830110 |
CNDT + Octreotide |
| GSM830111 |
KRJ-1 |
| GSM830112 |
QGP |
| GSM830113 |
NCIH720 |
| GSM830114 |
NCIH727 |
| GSM830115 |
LCM |
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| Relations |
| BioProject |
PRJNA148563 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE33568_RAW.tar |
4.1 Mb |
(http)(custom) |
TAR (of CEL, TXT) |
| Processed data included within Sample table |
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