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Series GSE33606 Query DataSets for GSE33606
Status Public on Nov 11, 2011
Title Gene expression changes in human hepatocytes exposed to VX (O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothiolate)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Organophosphorus compounds induce hepatotoxicity through currently unknown mechanisms, which need to be unraveled by a comprehensive and systematic approach such as genome-wide gene expression analysis.
We used microarrays to study gene expression changes in human hepatocytes after exposure to VX, and identified pathways underlying these changes.
 
Overall design Human hepatocytes were exposed to sublethal concentrations (0, 0.1, 10 μM) of VX. RNA were extracted at different timepoints (0, 6 h) after VX exposure and hybridized to Affymetrix microarrays. Four biological repeats were used for each condition.
 
Contributor(s) Gao X, Lin H, Ray R, Ray P
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Submission date Nov 10, 2011
Last update date Mar 25, 2019
Contact name Xiugong Gao
E-mail(s) xiugong.gao@amedd.army.mil
Organization name Walter Reed Army Institute of Research
Street address 503 Robert Grant Ave
City Silver Spring
State/province MD
ZIP/Postal code 20910
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (15)
GSM830925 hNHEPS_control_0 h_rep1
GSM830926 hNHEPS_control_0 h_rep2
GSM830927 hNHEPS_control_0 h_rep3
Relations
BioProject PRJNA148529

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE33606_RAW.tar 71.0 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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