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| Status |
Public on Nov 11, 2011 |
| Title |
Gene expression changes in human hepatocytes exposed to VX (O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothiolate) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Organophosphorus compounds induce hepatotoxicity through currently unknown mechanisms, which need to be unraveled by a comprehensive and systematic approach such as genome-wide gene expression analysis.
We used microarrays to study gene expression changes in human hepatocytes after exposure to VX, and identified pathways underlying these changes.
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| Overall design |
Human hepatocytes were exposed to sublethal concentrations (0, 0.1, 10 μM) of VX. RNA were extracted at different timepoints (0, 6 h) after VX exposure and hybridized to Affymetrix microarrays. Four biological repeats were used for each condition.
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| Contributor(s) |
Gao X, Lin H, Ray R, Ray P |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 10, 2011 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Xiugong Gao |
| E-mail(s) |
xiugong.gao@amedd.army.mil
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| Organization name |
Walter Reed Army Institute of Research
|
| Street address |
503 Robert Grant Ave
|
| City |
Silver Spring |
| State/province |
MD |
| ZIP/Postal code |
20910 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA148529 |
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