 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Nov 24, 2011 |
| Title |
Gene Expression Analyisis of T-ALL LOUCY cell lines treated with ETV6 siRNA vs. scramble control siRNA |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Transcriptional effects of ETV6 inactivation in immature T-ALL were investigated by gene expression analysis upon siRNA-mediated knockdown of ETV6 in LOUCY cells, a T-ALL cell line with a transcriptional program highly related to that of immature T-ALLs. Gene Set Enrichment Analysis (GSEA) of the ETV6 knockdown signature showed a significant enrichment in genes characteristically upregulated in ETV6 mutant immature T-ALLs including HOXA13, PRDM16, PTEN and CD33.
|
| |
|
| Overall design |
4 samples were analyzed: two biological replicates for each experimental group.
|
| |
|
| Contributor(s) |
Van Vlierberghe P, Ambesi-Impiombato A, Perez-Garcia A, Haydu EJ, Rigo I, Hadler M, Tosello V, Della Gatta G, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Rue M, Ferrando AA |
| Citation(s) |
22162831 |
| Submission date |
Nov 18, 2011 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Alberto Ambesi-Impiombato |
| Organization name |
Columbia University
|
| Department |
ICG
|
| Street address |
1130 St. Nicholas Avenue
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10032 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA148045 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE33820_RAW.tar |
26.2 Mb |
(http)(custom) |
TAR |
| GSE33820_non-normalized.txt.gz |
622.3 Kb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...