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| Status |
Public on Aug 31, 2012 |
| Title |
The effect of pertussis toxin on lung airway gene expression during B. pertussis infection in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Genome-wide expression analysis of mouse lung responses to Bordetella pertussis infection and the effects of pertussis toxin
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| |
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| Overall design |
Total lung RNA from wild-type and pertussis toxin-defficient B. pertussis-infected mice at two and four days post inoculation compared to control, mock-infected mice. Seven-week old female BALB/c mice were intranasally inoculated with 1 x 106 CFU WT B. pertussis (Tohama I), 1 x 106 CFU ΔPT (WT carrying a PT deletion), or 30 x 106 CFU of the ΔPT strain. Whole lung tissue was collected from mice sacrificed at 2 and 4 days post inoculation (n = 3 per group per time point). Control mice were inoculated with PBS and sacrificed 2 days post inoculation (n = 2).
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| |
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| Contributor(s) |
Connelly CE, Sun Y, Carbonetti NH |
| Citation(s) |
23027529 |
| Submission date |
Nov 29, 2011 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Nicholas Carbonetti |
| E-mail(s) |
ncarbone@umaryland.edu
|
| Organization name |
University of Maryland Baltimore
|
| Department |
Microbiology and Immunology
|
| Lab |
Carbonetti Lab
|
| Street address |
685 W. Baltimore St. HSF I-380
|
| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21201 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
|
| Samples (20)
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|
| Relations |
| BioProject |
PRJNA150639 |
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